髓样分化因子88的研究进展:把握TLR信号通路中的瓶颈  

Myeloid Differentiation Factor 88 Is The Bottle Neck of TLR Signaling Pathway

作　　者：章烈[1,2] 李园[2,3] 周总光[1,2] 

机构地区：[1]四川大学华西医院胃肠外科中心,四川成都610041 [2]四川大学华西医院消化外科实验室,四川成都610041 [3]四川大学华西医院小儿外科,四川成都610041

出　　处：《中国普外基础与临床杂志》2013年第6期685-690,共6页Chinese Journal of Bases and Clinics In General Surgery

基　　金：国家自然科学基金重点项目(项目编号:30830100);国家自然科学基金-面上项目(项目编号:30972924)~~

摘　　要：目的总结髓样分化因子88(myeloid differentiation factor 88,MyD88)在Toll样受体(toll like receptor,TLR)信号通路中的作用、MyD88与相关疾病的关系及其潜在的应用价值。方法收集近年来国内外有关MyD88在TLR信号通路中的作用及其与相关疾病关系的文献并作综述。结果 MyD88是一种重要的接头蛋白,在TLR信号通路中处于节点位置,起到承上启下的作用,是通路中的"瓶颈"。其传导的信号可导致下游多种转录因子的激活,从而启动先天性免疫反应,并且其与多种疾病的发生均有关。结论 MyD88是TLR信号通路的核心接头蛋白,在先天性免疫、获得性免疫和多种疾病的发生中均起着重要作用,是一个潜在的临床疾病的治疗靶点。Objective To summarize the important role of myeloid differentiation factor 88（MyD88）in toll like receptor（TLR）signaling pathway,and to summarize the relationship between MyD88 and relative diseases,and its potential application value.Methods Domestic and international publications online involving the role of MyD88 in TLR signaling pathway and the influence of MyD88 in some kinds of diseases in recent years were collected and reviewed.Results MyD88 was an important adapter protein,and played a connecting role in the TLR signaling pathway.It was the bottle neck of TLR signaling pathway,and could lead to the activation of many transcription factor to initiate innate immune response.It was also related to a variety of diseases.Conclusions MyD88 is the key adapter protein in TLR signaling pathway.It plays an important role in innate immunity,acquired immunity,and a variety of diseases,so it is a potential therapeutic target.

关 键 词：髓样分化因子88 TOLL样受体 信号通路 接头蛋白 应用价值 

分 类 号：R392.11[医药卫生—免疫学]