胃癌遗传学及表遗传学研究进展  

Advances on promotion of genetics and epigenetics in gastric cancer

作　　者：陆俊骏[1] 钱烨 连强[1] 

机构地区：[1]上海中医药大学附属上海市中医医院肿瘤科,上海200071 [2]上海市中医药大学附属岳阳中西医结合医院内科,上海200437

出　　处：《中国医药导报》2013年第19期43-46,共4页China Medical Herald

摘　　要：胃癌是病死率较高的恶性肿瘤之一,其发生与发展是多种因素交互作用的结果,包括环境、饮食、遗传、幽门螺杆菌感染、慢性炎症浸润、癌前病变等。随着对胃癌研究的不断深入,目前研究的焦点主要集中在遗传学及表观遗传学改变,包括DNA甲基化、组蛋白修饰、非编码RNA的改变、基因突变、基因杂合丢失和微卫星不稳定等。本文就遗传学及表遗传学改变在胃癌的诊断、预后预测及治疗等方面的研究进展做一综述。Gastric cancer is one of the malignant tumors with higher mortality rate, and its occurrence and development is the result of the interaction of many factors, including environment, diet, genetic, Helicobacter pylori infection, chronic inflammatory infiltration, precancerous lesions. With the deepening of the gastric cancer research, the focus of the present study is mainly focused on the genetics and epigenetic changes, including DNA methylation, histone modifications and changes in non-coding RNA, gene mutation, loss of heterozygosity and microsatellite instability. This article on genetics and epigenetic alterations in gastric cancer diagnosis, prognostic and therapeutic aspects of research progress are reviewed.

关 键 词：胃癌 遗传学 表观遗传学 非编码RNA DNA甲基化 组蛋白修饰 

分 类 号：R735.2[医药卫生—肿瘤]