阿魏酸哌嗪联合盐酸罗格列酮对糖尿病肾病患者血清C反应蛋白、肿瘤坏死因子-α及白介素-6水平的影响  

Effect of Piperazine Ferulate combined with Rosiglitazone Hydrochloride on serum levels of c-reactive protein, tumor necrosis factor-α and interleukin-6 in diabetic nephropathy patients

作　　者：王伟国[1] 沈建强[2] 

机构地区：[1]浙江省杭州市第一人民医院西药库,浙江杭州310006 [2]浙江省湖州市中心医院泌尿外科,浙江湖州313000

出　　处：《中国医药导报》2013年第19期97-99,共3页China Medical Herald

基　　金：浙江省医药卫生科学研究基金项目计划(编号2006B124)

摘　　要：目的探讨阿魏酸哌嗪联合盐酸罗格列酮治疗早期糖尿病肾病的疗效及对患者血清C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)及白介素-6(IL-6)水平的影响。方法 80例糖尿病肾病患者,随机分为观察组和对照组。对照组:采用卡托普利治疗糖尿病肾病。观察组:采用阿魏酸哌嗪联合盐酸罗格列酮治疗糖尿病肾病。观察两组治疗效果。结果治疗4周后,观察组患者的总有效率82.50%高于对照组总有效率52.50%,差异有显著性(P<0.01)。治疗4周后,观察组患者的24 h尿蛋白定量及Scr分别为(1.49±0.51)g/24 h、(132.85±18.91)μmol/L均优于对照组患者(2.19±0.58)g/24 h、(189.34±17.56)μmol/L,差异有高度统计学意义(P<0.01)。治疗4周后,观察组患者的UAER为(109.0±28.2)mg/24 h少于对照组(150.4±29.7)mg/24 h,差异有高度统计学意义(P<0.01)。治疗4周后,观察组患者的血清CRP、TNF-α及IL-6改善情况均优于对照组患者的改善情况,差异有高度统计学意义(P<0.01)。结论阿魏酸哌嗪联合盐酸罗格列酮治疗早期糖尿病肾病患者疗效可靠,不但能改善患者的24 h尿蛋白、血肌酐及尿白蛋白排泄率,还可以明显改善患者的血清CRP、TNF-α及IL-6水平。Objeαive To explore the effeαs of piperazine ferulate combined with rosiglitazone hydrochloride in the treatment of diabetic nephropathy （DN） at an early stage and the impaαs on serum levels of C-reactive protein （CRP）, tumor necrosis faαor-α （TNF-α） and interleukin-6 （IL-6）. Methods 80 patients with DN were randomly divided into observation group and control group. In the control group, patients were treated by captopril, while in the observation group, patients were provided with piperazine ferulate and rosiglitazone hydrochloride. The effeα of treatment in two groups were compared. Results After 4-week treatment, the total effeαive rate in the observation group was 82.50%, higher than that in the control group （52.50%）, with a significant difference （P 〈 0.01）. The 24-hour urine protein excretion and serum creatinine （Scr） in the observation group were （1.49±0.51） g/24 h and （132.85±18.91） μmol/L, which were both superior tO those in the control group, （2.19±0.58） g/24 h and （189.34±17.56） μmol/L respeαively （P 〈 0.01）. The urinary albumin excretion rate （UAER） in the observation group was （109.0±28.2） mg/24 h less than that in the control group （150.4±29.7） mg/24 h with a statistical difference （P 〈 0.01）. Besides, the conditions of serum CRP, TNF-α, and IL-6 in the observation group were all superior to those in the control group in a great difference （P 〈 0.01）. Conclusion In the treatment of DN patient, piperatine ferulate combined with rosiglitazone hydrochloride obtains a reliable effeα, which not only accelerates excretion rates of 24-hour urine protein, Scr, and urinary albumin, but also improves patient＇s serum levels of CRP, TNF-α, and IL-6.

关 键 词：阿魏酸哌嗪 盐酸罗格列酮 卡托普利 糖尿病肾病 尿白蛋白排泄率 C反应蛋白 肿瘤坏死因子-Α 白介素-6 

分 类 号：R587.2[医药卫生—内分泌]