四川江油附子新的强心成分  

A New Cardiac Principle Isolated from Jiangyou Fuzi (Aconitum carmichaeli Debx.)

作　　者：韩公羽[1] 梁华清[1] 廖耀中 刘明珠[1] 戴富宝 

机构地区：[1]第二军医大学药学院植物化学教研室,200433 [2]第二军医大学药学院精密仪器室,200433

出　　处：《第二军医大学学报》1991年第1期10-13,共4页Academic Journal of Second Military Medical University

摘　　要：从四川江油附子(Aconitum carmichaeli Debx.)水溶性部分首次分离得到一种单体,经元素分析,光谱鉴定(IR,UV,Ms,~1H及^(13)C-NMR等数据分析)证明是尿嘧啶[Uracil(Ⅰ),2,4-Diketo-pyrimidine]。其对蟾蜍离体心脏用5μmol/L,具有明显的加强心肌收缩作用(P<0.01),作用随剂量增加与时间延长而逐渐增强,且不影响心率(P>0.05)。与合成品尿嘧啶[Uracil(Ⅱ)]对照,二者强心作用一致,用药3min后估计尿嘧啶(Ⅰ)及尿嘧啶(Ⅱ)增加50％的效应剂量分别为4.17μmol/L,4.68μmol/L。二者都不影响心率,认为是一种新型的强心成分。Uracil (I) (2,4-Diketo-pyrimidine) was isolated from the radix aconiti collected from Jiangyou region of Sichuan Province.The chemical structure of this principle was determined by elemental analysis,IR,UV,MS,'H and 13C-NMR spectral data. The experiments were made to study the effect of uracil (I) on the cardiac contractile force and beating rate of the isolated toad hearts in comparison with uracil (II) (artificial synthesis). The results indicated that the 5μmol/L of uracil (I) and uracil (II) both had the effect of increasing the amplitude of myocardial contraction (P<0.01) and did not influence the toad heart rate (P>0.05) at 3 and 5 min. When the concentration was increased to 10 and 20μmol/L, the amplitudes of myocardial contraction were more incremental and 3 min later,the estimated value of uracil (I) and uracil (II) to increase the amplitude of myocardial contraction by 50% approached to 4.17 and 4.68, respectively. As described above, uracil (I) is a new cardiotonic in Jiangyou Fuzi.

关 键 词：附子 强心剂 成分 

分 类 号：R284.2[医药卫生—中药学]