慢性噪声暴露对听觉中枢的影响  

Auditory Center Affected by Chronic Noise Exposure

作　　者：范静平 陆书昌 胡正元[2] 梁振幅[2] 王云景[2] 

机构地区：[1]长征医院耳鼻喉科,200003 [2]海军医学研究所,上海200433

出　　处：《第二军医大学学报》1991年第3期259-261,共3页Academic Journal of Second Military Medical University

摘　　要：为探讨慢性噪声暴露对听觉中枢的影响,本实验采用7只豚鼠进行连续噪声暴露,强度105dBA,每天8h,暴露45d后断头处死,立即取上橄揽体及下丘制作电镜标本观察,发现神经细胞内线粒体肿胀、嵴断裂,线粒体膜破裂或呈气球样变。粗面内质网扩张,糖原颗粒脱落,滑面内质网肿胀扩张,细胞间质水种,突触小泡减少,细胞核仁靠边,核染色质减少,神经纤维髓鞘板层分离、肿胀和断裂。细胞内溶酶体和次级溶酶体增多。结果表明,慢性噪声暴露可引起听觉中枢神经细胞内超微结构、神经细胞本身及神经纤维的损害,并且这些损害多属不可逆性。In order to study the effect of chronic noise exposure on auditory center, seven guinea pigs were .exposured to 105 dB A noise 8h daily for 45 d. Then the animals were killed by decapitation. The superior olive and inferior colliculus were taken immediately to make the samples of electron microscope. The mitochondria swelling, membrane rupture, cristae breaking, ballooning degeneration were found. The rough surfaced endoplasmic reticulum was swollen and expanded. The lysosome and secondary lysosome were increased. The cell interstitial edema and synaptic besicle decrease were observed. The nuclear chromatid was decreased and nucleolus was kept to the side. The laminae of neurilemma of nerve fibers were dissociated, swollen and broken. The results indicate that the ultrastructure, neural cells and fibers in the auditory center are damaged by chronic noise exposure and most of these damages are irreversible.

关 键 词：噪声 上橄榄体 下丘 透射电镜 

分 类 号：R764.5[医药卫生—耳鼻咽喉科]