质谱技术的新进展及其在药物研究中的应用  

Recent Progresses on Mass Spectrometry and Their Progresses Applications in Pharmaceutical Analysis

作　　者：程纯儒[1,2] 丁杰[1,2] 杨义[1,2] 杨敏[3] 周振星[4] 李再新[1,2] 

机构地区：[1]四川理工学院化学与制药工程学院,四川自贡643000 [2]四川理工学院制药工程技术与应用研究所,四川自贡643000 [3]中国科学院上海药物研究所,上海201203 [4]四川省食品药品检验所,成都610097

出　　处：《四川理工学院学报（自然科学版）》2013年第3期11-15,共5页Journal of Sichuan University of Science & Engineering(Natural Science Edition)

基　　金：国家自然科学基金项目(81001630);四川理工学院人才引进项目(2012RC15;2012RC17);自贡市科技局项目(11GC016)

摘　　要：近年来,随着对药品安全问题的重视,药品检测部门和药物研发机构对分析方法的要求越来越高。质谱由于具有高灵敏度、高选择性的优点,在药物分析和药物代谢等研究领域获得了广泛的应用。质谱技术的发展也非常迅速,各种类型的杂交质谱、高端质谱层出不穷。针对质谱仪器构造结构和应用的问题,概述了目前常用和最新的质谱仪器,以及它们在药物研究中的应用。Recent years, government pays much attention to the issues of drug safety. In order to assure the quality of the drugs, better analytical methods are required. Mass spectrometry has the advantages of high sensitivity and selectivity, and has been widely used in the pharmaceutical analysis and drug metabolism. It has developed quickly for the last two decades and various types of hybrid and high-end mass spectrometry are emerging in an endless. Therefore, the new instrumentations and their applications in the drug analysis were summarized to solve the structure and application problems of mass spectrometry instrument.

关 键 词：药物研究 质量控制 质谱技术 杂交质谱 

分 类 号：R91[医药卫生—药学]