渝东南地区艰难梭状芽胞杆菌流行现状及高危因素的研究  被引量:3

The epidemic status and risk factors of clostridium difficile nosocomial infections in the southeast ChongQing area

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作  者:刘忠和 熊小平 陈春燕 马华兰 王于梅 候章梅 

机构地区:[1]重庆市黔江中心医院,409000

出  处:《国际消化病杂志》2013年第3期201-203,共3页International Journal of Digestive Diseases

基  金:重庆市卫生局课题(2010-2-368)

摘  要:目的探讨渝东南地区艰难梭状芽胞杆菌(CD)院内感染流行现状及危险因素。方法筛选并收集2012年3月渝东南地区三家医院的5783例住院患者的粪便标本,采用大便常规及CD的A和B毒素ELISA法检测大便标本。分析CD院内感染的流行情况及危险因素。结果渝东南地区CD院内感染发病率为0.40%。其中,黔江中心医院发病率为0.38%;酉阳县人民医院发病率为0.42%;彭水县人民医院发病率为0.40%。三家医院相比,差异无统计学意义(P>0.05)。使用抗生素患者发病率为2.1%,与未使用抗生素患者(发病率0.1%)相比,差异有统计学意义(P<0.05)。使用免疫抑制剂与未使用免疫抑制剂患者相比,差异有显著统计学意义(P<0.01)。重大手术患者与无重大手术患者相比,差异有显著统计学意义(P<0.01)。结论渝东南地区CD院内感染发病率为0.40%。使用抗生素及免疫抑制剂、重大手术患者均为CD院内感染高发人群。Objective To investigate the epidemic status and risk factors of clostridium difficile nosocomial infections in the southeast ChongQing area. Methods We screened and collected the excrement specimens of the 5783 patients in the three hospital in the southeast ChongQing area during the March in 2012, and detected these specimens by clostridium difficile toxin A or B ELISA. Some patients underwent colonoscopy examination. And we analyzed the risk factors of clostridium difficile nosocomial infections. Results The incidences of clostridium difficile nosocomial infections in the QianJiang center hospital, YouYang people's hospital, PengShui people's hospital and total population were 0. 38%, 0. 42%, 0. 40%o and 0. 40%, respectively. The incidences in the three hospitals were no significant difference (P〉0.05). There was significant difference between the patients used antibiotics and the patients without, and also in the patients used immunosuppressive had higher incidence to the patients without (P〈0. 05) . Major operation compared with no major operation patients, the difference was statistically significant (P〈0. 01 ). Conclusion The incidence of clostridium difficile nosocomial infections in southeast ChongQing area was 0.40%. Antibiotics and immune inhibitor used, major surgery are high-risk factors in clostridium difficile nosocomial infections.

关 键 词:艰难梭状芽胞杆菌 院内感染 高危因素 

分 类 号:R181.3[医药卫生—流行病学]

 

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