麻醉和去减压神经对酮舍林降压作用的影响  

Effects of Anaesthesia and Sinoaortic Denervation on the Hypotensive Action of Ketanserin

作　　者：苏定冯[1] 杨友才[1] 谢京儿 

机构地区：[1]第二军医大学训练部药理学教研室,200433

出　　处：《第二军医大学学报》1991年第5期401-404,共4页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金 No 3880743

摘　　要：在清醒自由活动大鼠和麻醉大鼠观察了麻醉和去减压神经(SAD)对酮舍林降压作用的影响。发现在麻醉状态下,酮舍林对SAD和假手术大鼠均有显著的降压作用,且它们的量-效曲线完全重合。但在清醒状态,酮舍林仅对SAD大鼠的降压作用呈明显的量-效关系。结果提示,酮舍林对清醒正常血压大鼠降压作用不明显与动物的动脉压力感受性反射的完整性有关。Effects of anaesthesia and sinoaortic denervation (SAD) on the hypotensive action of , ketanserin were studied in rats. It was found that the dose-effect curves of kelanserin on blood pressure were the same between SAD and sham-operated rats under anaesthesia. However, in concious free ly moving rats, SAD sharpened the dose-effect curves. It is concluded that the lack of hypotensive effect of ketanserin in conscious normotensive animals is due in large part to the integrity of the arterial baroreflex.

关 键 词：麻醉 血压 酮舍林 降压剂 

分 类 号：R972.4[医药卫生—药品]