依托咪酯在老年患者诱导时抑制气管插管反应的最低有效量  

The mininal effective dose of etomidate required in preventing tracheal iutubation response during induction in elderly patients

作　　者：汪卫兵[1] 檀彧庆[1] 肖敬波[1] 胡胜红[1] 王仕芳[1] 王胜斌[1] 

机构地区：[1]安庆市立医院麻醉科,246003

出　　处：《安徽医学》2013年第6期733-735,共3页Anhui Medical Journal

摘　　要：目的测定依托咪酯在老年患者诱导时抑制气管插管反应的最低有效量即半数有效量(ED50)。方法 35例拟行气管插管全身麻醉老年患者(ASAⅠ～Ⅲ级),诱导方法:第1例患者采用依托咪酯0.2 mg/kg静脉注射,其后各患者的药物剂量依序贯法进行选择,若患者的平均动脉压(MAP)或心率(HR)增快大于20%,为阳性,则下例患者取高一级别剂量,若患者的平均动脉压或心率增快小于20%,为阴性,则下例患者取低一级别剂量,相邻级别的药物剂量比为1∶1.1,而后维库溴铵0.1 mg/kg及芬太尼4μg/kg静脉注射。结果在老年患者行气管插管全身麻醉诱导时依托咪酯抑制气管插管反应的ED50为0.244 mg/kg,95%CI为0.158～0.330 mg/kg。结论依托咪酯在老年患者诱导时抑制气管插管反应的最低有效量即ED50为0.244 mg/kg,其95%CI为0.158～0.330 mg/kg。Objective To determine the mininal effective dose of etomidate required in the prevention of tracheal iutubation response during induction in elderly patients. Methods Thirty-five patients（ASA I -llI ） scheduled for surgery under general anesthesia with tracheal iutubation were enrolled in the study. The method of induction： the first dose of etomidate was 0.2 mg/kg, and the next dose was determined ac- cording to an up-down sequential method, and the ration of adjacent dose rank was 1.1, and then vecuronium 0.1 mg/kg and fentanyl 4 ug/kg intravenous injected. The positive defined as the MAP or HR increased more than 20%, and negative defined as the MAP or HR increased not more than 20%. Results The mininal effective dose of etomidate required in preventing tracheal iutubation response during induction in el- derly patients was 0.244 mg/kg, and 95%CI 0.158 to 0.330 mg/kg. Conclusion The EDS0 of etomidate required in the prevention of tracheal iutubation response during induction in elderly patients is 0.244 mg/kg, and 95%CI 0.158 to 0.330 mg/kg.

关 键 词：老年 依托咪酯 半数有效量 气管插管 诱导 

分 类 号：R614[医药卫生—麻醉学]