硝喹对约氏疟原虫卵囊和子孢子作用的观察  

Observation of Nitroquine Effect on Sporogonic Development of Plasmodium yoelii

作　　者：黄复生[1] 王兴相[1] 

机构地区：[1]第三军医大学训练部寄生虫学教研室,630038

出　　处：《第三军医大学学报》1991年第1期1-4,共4页Journal of Third Military Medical University

摘　　要：本文对硝喹在鼠疟孢子增殖期作用的超微结构进行了观察。扫描电镜观察表明,卵囊数量减少,个体较小,晚期卵囊退化,外形不规则;透射电镜观察显示,核膜肿胀,核基质浓缩,自噬泡明显可见,线粒体空泡变,残余体增多。子孢子核膜增厚,空泡变。The effects of nitroquine on the sporogonic development of Plasmo-dium yoelii were observed under electron microscopy. The female mosquitoes were fed directly with 10% sucrose solution containing 0.1%Nitroquine.It was found that the oocysts were smaller and markedly degenerated as compared with that of the control. The surface of the oocysts was rough and uneven. Under a transmission electron microscope, the cytoplasm of the affected oocysts contained vacuoles; the membane of mitochondria and uncleus was damaged; and the number of residual bodies increased.No sporoblast formation was seen in most of the affectes oocysts. The nuclear membrane of the degenerated sporozoites was thickened and the density of nuclear matrix decreased markedly as compared with that of the control. These results indicate that the nucleus and the membrane are mainly affected during the sporogonic development of P. yoelii by nitroquine.

关 键 词：硝喹 约氏疟原虫 孢子增殖 抗疟药 

分 类 号：R978.61[医药卫生—药品]