CD4＋CD28-T细胞DNA甲基化异常与免疫系统疾病的关系  

Correlation between abnormal DNA methylation in CD4＋CD28-T cell and immune disease

作　　者：贾茹[1] 张晓[1] 黄立娟[1] 

机构地区：[1]哈尔滨医科大学附属第二医院检验科,150086

出　　处：《国际免疫学杂志》2013年第4期290-293,共4页International Journal of Immunology

摘　　要：在急性冠脉综合征（ACS）和一些自身免疫性疾病中发现CD4＋CD28-T细胞，该细胞具有细胞毒性，抵抗细胞凋亡和浸润组织能力。CD4＋CD28-T细胞内的DNA甲基化异常可导致一些基因的过度表达，与疾病的发生发展密切相关。深入研究CD4＋CD28-T细胞功能特性及CD4＋CD28-T细胞内DNA甲基化在疾病中的作用，有利于阐明疾病的发病机制，为治疗疾病提供新的线索。CD4＋CD28-T cells are found in acute coronary syndrome and some autoimmune diseases. The characteristics of these cells include their cytotoxic potential, resistance to apoptosis and tissue-infiltrating capacity. The aberrant expression of genes in the CD4＋CD28-T cells might due to abnormal DNA methylation. These genes are closely related with the development of diseases. Further study on CD4＋CD28-T cell features and DNA methylation in diseaseswill, elucidate the pathogenesis of diseases and provide new clues for the treat- ment.

关 键 词：CD4+CD28-T细胞 DNA甲基化 急性冠脉综合征 免疫系统疾病 

分 类 号：R593.2[医药卫生—内科学]