慢性咳嗽患儿呼出气一氧化氮与特应性体质及血清总免疫球蛋白E水平的相关性研究  

Correlation of exhaled nitric oxide with atopy and serum IgE levels in children with chronic cough

作　　者：季秀梅[1] 周晓[1] 陈菊萍[1] 王凯旋[1] 王大燕[1] 陈步青[1] 

机构地区：[1]金华市中心医院儿科,321000

出　　处：《浙江医学》2013年第11期1013-1015,共3页Zhejiang Medical Journal

基　　金：金华市科学技术研究计划项目(2011-3-022)

摘　　要：目的研究慢性咳嗽患儿呼出气一氧化氮(fractional exhaled nitric oxide,FeNO)与特应性体质及血清总免疫球蛋白E(TIgE)水平的相关性。方法对91例慢性咳嗽的患儿进行FeNO、血TIgE的检测及变应原皮肤点剌试验并进行分组对比。结果特应性体质组FeNO值为(29.74±14.24)ppb,TIgE为(483.95±384.57)IU/ml,非特应性体质组FeNO值为(13.82±7.91)ppb,TIgE为(154.09±143.42)IU/ml,差异均有统计学意义(均P<0.05)。血清TIgE增高患儿FeNO值为(29.15±15.30)ppb,血清IgE正常患儿FeNO值为(16.22±9.75)ppb,差异有统计学意义(P<0.05)。相关性分析发现FeNO水平与过敏原数目不存在相关(P=0.278)。结论特应性体质可使慢性咳嗽患儿FeNO水平明显升高,而FeNO与皮肤过敏原阳性数目无明显相关性,在诊断哮喘时应注意特应性体质的存在。Objective To investigate the correlation of exhaled nitric oxide （FeNO） with atopy and serum total lgE（TlgE） levels in children with chronic cough. Methods Ninety one children diagnosed as chronic cough in respiratory clinic from Jan- uary 2011 to October 2012 were enrolled. The FeNO and serum TigE were measured and immunopathogen skin prick tests were performed. Results FeNO and serum TigE in the case group were significantly higher than those in control group （29.74 ± 14.24ppb vs 13.82± 7.91ppb; 483.95± 384,571U/ml vs 154.09± 143.42 IU/ml, both P〈0.05）. FeNO value in children with elevated serum TIgE was higher than that in children with normal serum TIgE （29.15 ± 15.30ppb vs 16.22 ±9.75ppb, P〈0.05）. Correlation analysis showed that FeNO was not correlated with the number of immunogen （P =0.278）. Conclusion Atopy in children with chronic cough will increase FeNO, while the FeNO value is not correlated to the number of immunogen,

关 键 词：呼出气一氧化氮 咳嗽 特应性 血清免疫球蛋白E 儿童 

分 类 号：R725.6[医药卫生—儿科]