右美托咪定用于抑制高血压患者全麻气管拔管期心血管反应的观察  

Effect of dexmedetomidine on preventing cardiovascular response during extubation period in patients with hypertension under general anesthesia

作　　者：刘文贵[1] 卓庆亮[1] 李雪萍[1] 刘才堂[1] 

机构地区：[1]中山大学附属东华医院麻醉科,广东东莞523110

出　　处：《临床医学》2013年第5期11-13,共3页Clinical Medicine

摘　　要：目的观察右美托咪定对高血压患者全麻气管拔管期心血管反应的影响。方法选择60例普外科及妇科行择期腔镜手术的高血压患者,ASAⅠ～Ⅱ级,年龄39～65岁,体质量52～78 kg,将患者随机分为右美托咪定组(A组)和对照组(B组),每组30例。手术结束前40 min,A组和B组分别使用微量输液泵静脉泵注右美托咪定0.8μg/kg和等量生理盐水,泵注时间15 min。记录患者麻醉诱导前(基础值)、拔管前、拔管时及拔管后1、5、10 min等各时段的收缩压(SBP)、舒张压(DBP)、心率(HR)和脉搏氧饱和度(SpO2)的变化。结果两组患者手术前SBP、DBP、HR、SpO2值差异无统计学意义(P﹥0.05),A组拔管期各时间点的变化和术前基础值比较,差异无统计学意义(P﹥0.05);B组SBP、DBP、HR在拔管前、拔管时及拔管后1、5 min与术前及A组同期比较差异有统计学意义(P﹤0.05)。结论手术结束前40 min静脉泵注0.8μg/kg右美托咪定能明显减轻高血压患者全麻拔管时的心血管反应。Objective To observe the effect of dexmedetomidine on preventing cardiovascular response during extubation period in patients with hypertension under general anesthesia.Methods Sixty ASAⅠorⅡpatients with hypertension underwent elective general surgery and gynecological laparoscopy were randomly divided into dexmedetomidine group（group A） and control group（group B）,with 30 cases in each group.Group A received dexmedetomidine 0.8 μg/kg via micropumps at 40 minutes before the end of operation.Group B received equal volume of normal saline.Systolic blood pressure（SBP）,diastolic blood pressure（DBP）,heart rate（HR） and pulse oxygen saturation（SpO2） were recordedat before intubation,before extubation,during extubation,and 1 minute,5 minutes and 10 minutes after extubation.Results Compared with group B,SBP,DBP and HR obviously decreased in group A before extubation,during extubation,and at one minute and 5 minutes after extubation（P0.05）.There were no significant differences in SpO2 between the two groups（P﹥0.05）.Conclusion Dexmedetomidine was effective on preventing cardiovascular response during extubation period in patients with hypertension under general anesthesia

关 键 词：右美托咪定 高血压 气管拔管 心血管反应 

分 类 号：R614[医药卫生—麻醉学]