地佐辛复合丙泊酚对腹腔镜胆囊切除患者苏醒期躁动的影响  

Effects of the dezocine-propofol on emergency agitation in laparoscopic cholecystectomy patients

作　　者：陶清[1] 王守义[1] 王明[1] 陈庆一[1] 

机构地区：[1]安徽省中医院麻醉科,合肥230031

出　　处：《临床医学》2013年第5期13-15,共3页Clinical Medicine

摘　　要：目的比较地佐辛复合丙泊酚与单纯使用地佐辛对腹腔镜胆囊切除患者苏醒期躁动的影响。方法 60例腹腔镜胆囊切除患者ASA分级Ⅰ～Ⅱ级,年龄20～60岁,将其随机分为三组:对照组(C组),地佐辛组(D组),丙泊酚复合地佐辛组(Z组)。入室后常规诱导插管,监测各项指标,静吸复合麻醉维持,根据各项指标调整给药速度及量,手术结束前15 min停所有维持药物。停药后进行如下处理:C组不用任何药物,D组给予地佐辛0.1 mg/kg,Z组给予地佐辛0.1 mg/kg及丙泊酚10μg/kg/min。记录拔管后5、10、15 min时行为疼痛评分、镇静评分及呼吸(HR)、平均动脉压(MAP)值。结果 D组与Z组停药后行为疼痛评分与C组比较明显降低,差异有统计学意义(P<0.05),且Z组效果优于D组,差异有统计学意义(P<0.05);各组各时点镇静评分比较差异无统计学意义(P>0.05);与初始比较,D组与Z组停药后HR、MAP均无明显改变,差异无统计学意义(P>0.05)。结论地佐辛复合丙泊酚可明显降低腹腔镜胆囊切除患者苏醒期躁动的发生率,且效果优于单纯地佐辛。Objective To compare the effects of the dezocine-propofol and the dezocine alonely on emergency agitation in laparoscopic cholecystectomy patients.Methods Sixty patients underwent laparoscopic cholecystectomy with ASA classification for Ⅰ-Ⅱ,20 to 60 years old,were randomly divided into three groups： the control group（group C）,the dezocine group（group D）,the dezocine-propofol group（group Z）.After entering operating room,conventional induction and intubation,indicators were monitored,intravenous-inhalation anesthesia were maintained.According to various indicators to adjust the speed of administration and amount,all maintenance drugs were withdrawed before 15 min at the end of surgery.After withdrawing the maintenance,taking treatment as： group C weren＇t given any drug,group D were given dezocine 0.1 mg/kg,group Z were given dezocine 0.1 mg/kg and propofol 10 μg/（kg·min）.Behavior pain score,sedation score and HR,MAP values at 5,10,15 min after extubation were recorded.Results Compared with group C,behavioral pain score in group D and group Z was significantly reduced,the difference was statistically significant（P0.05）,and group Z was better than group D,the difference was statistically significant（P0.05）;sedation score of each group at each time point has no significantly difference（P0.05）;compared with the initial,HR,MAP had no significantly difference in group D and group Z,the difference was not statistically significant（P0.05）.Conclusion The dezocine-propofol can significantly reduce the incidences of emergency agitation in laparoscopic cholecystectomy patients,and is more effective than the dezocine alonely.

关 键 词：地佐辛 丙泊酚 腹腔镜胆囊切除 苏醒期躁动 

分 类 号：R614[医药卫生—麻醉学]