双藤痹痛凝胶膏剂的体外释放及其透皮吸收  

Experimental study on in vitro release and transdermal absorption of Shuangteng Bitong gel ointment

作　　者：夏裕发[1] 李煌[1] 张勋[1] 徐伟[1] 陈立典[2] 褚克丹[1] 陈瑞兰[1] 

机构地区：[1]福建中医药大学药学院,福建福州350108 [2]福建中医药大学康复医学院,福建福州350108

出　　处：《中国医院药学杂志》2013年第12期925-928,共4页Chinese Journal of Hospital Pharmacy

基　　金：国家"十二五"科技支撑计划项目(编号:2011BAI01B05);福建省科技厅重大专项(编号:2009YZ0001-1-1);福建省科技厅创新平台项目(编号:2010Y2004)

摘　　要：目的:考察双藤痹痛凝胶膏剂的药物体外释放和透皮吸收行为。方法:采用垂直式Franz扩散池,HPLC法测定接收液中雷公藤甲素和青藤碱的含量,模拟出雷公藤甲素和青藤碱体外释放及透皮吸收的动力学方程式。结果:雷公藤甲素和青藤碱的累积透皮吸收百分率分别为29.05%,23.16%,体外累积释放百分率分别为69.14%,65.53%。结论:双藤痹痛凝胶膏剂的药物透皮吸收行为符合零级动力学过程,体外释放行为符合Higuchi方程。OBJECTIVE To investigate the in vitro release and transdermal absorption of Shuangteng Bitong gel ointment.METHODS Using Franz diffusion pool,the content of triptolide and Sinomenine in absorption liquid were determined by HPLC,some dynamic equations about in vitro release and transdermal absorption were obtained.RESULTS The acumulative skin permeation percentage of triptolide and sinomenine was 29.05% and 23.16%,respectively,the acumulative in vitro release percentage of triptolide and sinomenine was 69.14% and 65.53%,respectively.CONCLUSION The transdermal absorption of Shuangteng Bitong gel ointment is a zero-order kinetics.The in vitro release behavior is in accordance with the Higuchi equation.

关 键 词：凝胶膏剂 雷公藤甲素 青藤碱 透皮吸收 释放 

分 类 号：R944[医药卫生—药剂学]