丁桂凝胶基质的配方优化筛选  

Selection of the optimized formula of Dinggui gel matrix

作　　者：朱力阳[1] 马建[1] 涂禾[1] 郭宏彦[1] 冯光富[1] 祝贺[1] 

机构地区：[1]四川省骨科医院,四川成都610041

出　　处：《中国医院药学杂志》2013年第12期931-933,共3页Chinese Journal of Hospital Pharmacy

基　　金：国家科技部科研院所技术开发研究专项资金项目(编号:2012EG145135)

摘　　要：目的:筛选丁桂凝胶膏剂的最佳配方。方法:应用正交试验法,以初黏力、持黏力、剥离强度为指标,考察所有组分在不同配比时丁桂凝胶膏剂的性能。结果:最佳的基质配比为NP-700∶卡波姆∶甘油∶甘羟铝∶酒石酸∶水(2∶0.8∶30∶0.1∶0.1∶67)。结论:该凝胶膏剂的配方有效、稳定。OBJECTIVE To select the best formula of Dinggui gel matrix. METItODS By using the orthogonal test, with the adhesive force, the holding adhesive power and the peeling strength as the indicators, the performances of the Dinggui gel matrix were observed when all the components were at different mixture ratio. RESULTS The best mixture ratio of the matrix was NP700 2, carbomer 0. 8, glycerol 30, glycinate aluminum 0. 1, tartaric acid 0. 1 and water 67. CONCLUSION This for- mula of the gel matrix is efficiency and steady.

关 键 词：凝胶膏剂 聚丙烯酸 卡波姆 正交试验 

分 类 号：R943[医药卫生—药剂学]