多指标综合评分法优选丹参饮口服液助悬工艺  

Optimization of suspending technology for Danshen decoction oral liquid by multi-index grading method

作　　者：蒲清荣[1] 黄锐[1] 赵剑[1] 陈玉兰[1] 杨光华[1] 李能源[1] 

机构地区：[1]泸州医学院附属中医医院,四川泸州646000

出　　处：《中国医院药学杂志》2013年第12期938-942,共5页Chinese Journal of Hospital Pharmacy

基　　金：泸州市科技局课题(编号:LSCQ<2010>41号)资助

摘　　要：目的:优选丹参饮口服液的助悬工艺。方法:采用正交试验法,以收膏率、丹参素钠和丹参酮ⅡA相对含量为综合评分指标,多指标优选丹参饮口服液的最佳助悬工艺。结果:最佳助悬工艺是:药液浓度比为1∶3,琼脂用量为每100 mL药液加入0.02 g,冷藏48 h。结论:优选的助悬工艺合理可行,稳定可靠,具可操作性和重复性。OBJECTIVE To optimize the suspending technology of danshen Decoction oral liquid.METHODS The orthogonal experiment was used to optimize the suspending technology on ointment rate and relative content of Danshensu-sodium and tanshinone ⅡA as comprehensive evaluation indexes.RESULTS The best suspending technology was the 100 mL concentration ratio of sample liquid 1∶3 with adding agar 0.02 g,refrigerated 48 h.CONCLUSION Optimized suspending technology for Danshen decoction oral liquid was reasonable,feasible,stable,reliable,operable and good reproducibility.

关 键 词：丹参饮口服液 丹参素钠 丹参酮ⅡA 助悬工艺 多指标 

分 类 号：R944[医药卫生—药剂学]