运动锻炼对高血压患者氧化应激及炎症因子的影响  

Effects of physical exercises on oxidative stress and inflammatory factor levels in patients with hypertension

作　　者：戴红艳[1] 郑霞[2] 何涛[1] 李晓鲁[3] 王正忠[1] 丁华民[1] 

机构地区：[1]青岛市市立医院心内科,山东省266011 [2]青岛市黄岛区中医院心内科 [3]山东省千佛山医院急诊科

出　　处：《中华临床医师杂志（电子版）》2013年第9期93-96,共4页Chinese Journal of Clinicians(Electronic Edition)

基　　金：青岛市公共领域科技支撑计划项目[2012-1-3-1-(2)-nsh]

摘　　要：目的观察运动锻炼对高血压患者氧化应激及炎症因子的影响。方法选取73例高血压患者随机分为干预组和对照组。干预组继续药物治疗的基础上给予为期6个月的运动锻炼,对照组药物治疗同前,并保持平静生活方式。结果通过6个月的运动锻炼,干预组和对照组比较结果显示体重[(69±8)kgvs.(73±8)kg]、收缩压[(137.7±5.8)mmHgvs.(141.7±6.9)mmHg]、舒张压[(81.7±4.7)mmHgvs.(84.9±5.9)mmHg]下降,血清丙二醛[(6.65±1.4)μmol/Lvs.(7.65±1.3)μmol/L]、高敏C反应蛋白[(6.68±1.76)mg/Lvs.(7.89±1.23)mg/L]、白细胞介素-6[(10.54±3.27)pg/mlvs.(12.95±4.35)pg/ml]、肿瘤坏死因子-α[(5.48±1.76)pg/dlvs.(7.68±3.26)pg/dl]降低,超氧化物歧化酶[(92.87±14.8)U/mlvs.(84.56±15.9)U/ml]、一氧化氮[(82.56±11.7)μmol/Lvs.(75.92±15.9)μmol/L]含量升高(均P<0.05)。结论运动锻炼能降低高血压患者体重、血压,还能改善高血压患者氧化应激及炎症状态。Objective To observe the effects of physical exercises on oxidative stress and inflammatory factor levels in patients with hypertension. Methods A total of 73 patients with essential hypertension were randomly assigned to the intervention group （n = 36;doing physical exercise once a day, 5 days a week ）or control group （n= 37,keeping sedentary life）. All the patients received standard treatment. At the beginning and at 6 months, body weight（BT） ,systemic blood pressure （SBP）, diastolic blood pressure （DBP） and heart rate （HR） were recorded, serum malondialdehyde （MDA）, superoxide disnmtase （ SOD ）, nitric oxide （ NO ）, hs-C reactive protein （hs-CRP） , intedeukin-6 （IL-6） and tumor necrosis factor-α （TNF-α） were measured. Results At 6 months, BT [ （69 ± 8） kg vs. （73 ±8）kg],SBP[ （137.7 ±5.8）mm Hgvs. （141.7 ±6.9）mm Hg],DBP [（81.7 ±4.7）mm Hgvs. （84.9 ± 5. 9） mm Hg ], serum MDA [ （6. 65 ± 1.4） pmol/L vs. （7. 65 ± 1.3 ） μmoL/L ], hs-CRP [ （6. 68 ± 1.76 ） mg/L vs. （7. 89 ± 1.23）mg/L] ,IL-6[ （10. 54 ± 3.27）pg/ml vs. （12.95 ±4. 35） pg/ml] and TNF-α[ （5.48 ± 1.76）pg/dl vs. （7. 68 ±3.26）pg/d13were significantly decreased in the intervention group when compared with the control goup （ all P 〈 0. 05 ）, while serum SOD [ （ 92. 87 ± 14. 8 ） U/ml vs. （ 84. 56 ± 15.9） U/ml ] and NO [ （ 82. 56 ± 11.7 ） μmoL/ L vs. （75.92 ± 15.9） μmol/L ] were significantly increased （ both P 〈 0. 05 ）. Conclusion Physical exercises could play a role in reducing body weight, blood pressure, improving oxidative stress and decreasing inflammatory factor levels in patients with hypertension.

关 键 词：高血压 运动 氧化性应激 炎症 

分 类 号：R544.1[医药卫生—心血管疾病]