注射用丹参多酚酸盐注射液对急性脑梗死患者血浆肿瘤坏死因子α及C反应蛋白的影响  

Study of Salvianolate on the levels of tumor necrosis factor-α and C-reactive protein in plasma of patients with acute cerebral infarction

作　　者：马增玉 吕建卫 

机构地区：[1]河北省邢台县医院内科,河北邢台054001

出　　处：《河北中医》2013年第6期899-901,共3页Hebei Journal of Traditional Chinese Medicine

摘　　要：目的观察注射用丹参多酚酸盐注射液对急性脑梗死患者血浆肿瘤坏死因子α(TNF-α)及C反应蛋白(CRP)的影响。方法将112例急性脑梗死患者随机分为2组。对照组56例予以常规治疗,治疗组56例在对照组治疗基础上加用注射用丹参多酚酸盐注射液。2组均4周为1个疗程,1个疗程后统计疗效,并观察治疗前后TNF-α及CRP水平的变化。结果治疗组总有效率90.1%,对照组总有效率75.0%,2组总有效率比较差异有统计学意义(P<0.05),治疗组疗效优于对照组。2组治疗后TNF-α及CRP均降低(P<0.05),但治疗组较对照组降低更明显(P<0.05)。结论注射用丹参多酚酸盐注射液治疗急性脑梗死疗效确切,其机制可能与抗炎症反应,保护脑细胞及血管内皮细胞有关。Objective To investigate the effect of Salvianolate for injection on the levels of tumor necrosis factor -α and C - reactive protein in plasma of patients with acute cerebral infarction. Methods 112 cases of acute cerebral infarction were randomly divided into two groups. 56 cases in control group were treated by conventional west- ern medicine. 56 patients in treatment group were treated by Salvianolate on the basis of conventional western medi- cine. The course was four weeks in two groups. The effect and levels of TNF -α and CRP were observed after a course. Results The total effective rate in treatment group （90.1% ） was higher than that in control group（75.0%, P 〈0. 05 ）. The levels of TNF - α and CRP after treatment were decreased as compared with those before treatment in two groups （P 〈 0.05 ）. But the decrease in treatment group was superior to that in control group（P 〈 0. 05 ）. Conclu- sion Salvianolate has definite effect on the treatment of acute cerebral infarction, mechanism may be related to the anti -inflammatory response, protecting brain cells and endothelial cells.

关 键 词：急性病 脑梗死 丹参酚 肿瘤坏死因子Α C反应蛋白质 中药疗法 

分 类 号：R282.710.7[医药卫生—中药学] R743.330.531[医药卫生—中医学]