芪苈强心胶囊对不同病因所致慢性心力衰竭患者心功能的影响  

Observation of Qili Qiangxin capsule on cardiac function in patients with chronic heart failure due to different causes

作　　者：孙利 谷春华[2] 高学东 杨立波 徐贵成[3] 

机构地区：[1]河北以岭医药研究院新药临床部,河北石家庄050035 [2]河北医科大学医药研究院医学生物统计中心,河北石家庄050035 [3]中国中医科学院广安门医院综合科,北京100053

出　　处：《河北中医》2013年第6期904-905,921,共3页Hebei Journal of Traditional Chinese Medicine

摘　　要：目的观察芪苈强心胶囊对不同病因所致慢性心力衰竭(CHF)患者心功能的影响。方法采用随机双盲、多中心、疾病分层临床试验设计方法,321例CHF患者中冠心病致CHF 185例,原发性高血压致CHF 136例,均予芪苈强心胶囊治疗,疗程4周,比较2组治疗前后心脏彩色多普勒超声心动图检测指标变化。结果 2组治疗前后心脏射血分数(EF)、每分钟心输出量(CO)、E峰与A峰比值(E/A)、左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)、每搏输出量(SV)、缩短分数(FS)比较差异均有统计学意义(P<0.05,P<0.01),2组治疗后心功能均明显改善。2组治疗前后差值除LVEDD、LVESD比较差异有统计学意义(P<0.05,P<0.01)外,其余指标比较差异均无统计学意义(P>0.05)。结论芪苈强心胶囊能明显改善CHF患者的心功能指标,对不同病因所致CHF均有明显疗效。Objective To investigate the effect of Qili Qiangxin capsule on cardiac function in patients with chronic heart failure due to different causes. Methods A randomized, double - blind, muhi - center, clinical trial de- sign disease stratification method was adopted,321 cases of chronic heart failure due to coronary heart disease and 185 patients with CHF due to primary hypertension were treated by Qili Qiangxin capsule for four weeks. The changes of heart color Doppler echocardiography before and after treatment were compared in two groups. Results There were significant differences between before and after treatment on ejection fraction （ EF）, cardiac minute output （ CMO）, E/A,LVSED,LVEDD,SV and FS in two groups （P 〈 0. 05 ,P 〈 0.01 ）. Cardiac function was significantly improved after treatment in two groups. There were significant differences between two groups on the changes of EF, CMO, E/A, SV and FS（ P 〈 0.05 ,P 〈 0. 01）. Conclusion Qili Qiangxin capsule can significantly improve cardiac function in patients with CHF, and has a significant effect on CHF for different causes.

关 键 词：慢性病 心力衰竭 强心药 胶囊 黄芪 葶苈子 心脏 

分 类 号：R541.610.531[医药卫生—心血管疾病] R259.416.1[医药卫生—内科学]