利妥昔单抗治疗系统性红斑狼疮出现血栓栓塞并文献复习  

Thrombosis Associated with Rituximab Therapy in Lupus Patients:A Rare Adverse Effect

作　　者：苏金梅[1] 陈华[1] 徐东[1] 周炜洵[2] 张烜[1] 张奉春[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院风湿免疫科,北京100032 [2]中国医学科学院北京协和医学院北京协和医院病理科,北京100032

出　　处：《中华临床免疫和变态反应杂志》2013年第2期151-153,I0004,共4页Chinese Journal of Allergy & Clinical Immunology

基　　金：国家自然科学基金(30901342)

摘　　要：目的与利妥昔单抗相关血栓的不良反应非常罕见,通过学习1例使用利妥昔单抗后出现严重血栓事件患者的临床特点,进一步了解利妥昔单抗的不良反应。方法详细报道1例系统性红斑狼疮(systemic lupus erythematosus,SLE)合并抗磷脂抗体综合征(anti phospholipid syndrome,APS)患者使用利妥昔单抗后出现血栓的临床表现。结果该患者在使用利妥昔单抗治疗3个月后,PLT正常,狼疮不活动,但出现下肢深静脉血栓和肺栓塞。结论利妥昔单抗治疗SLE有效,但给予SLE合并APS患者使用时要警惕血栓形成的风险。Objective Thrombosis associated with rituximab is rare. We study the clinic manifestation of the patient who developed severe thrombosis after treated with rituximab in order to learn more about side-effects of rituximab. Methods A patient with systemic lupus erythematosus （SLE）complicated with anti phospholipid syndrome （APS）, who was developed severe thrombosis after treated with rituximab, is described in detail. Results A patient was improved after rituximab treatment. But the patient developed deep vein thrombosis and pulmonary embolism three months after rituximab therapy. Conclution Rituximab is effective in SLE, but it has also been associated with some potentially severe adverse effects such as thrombosis.

关 键 词：利妥昔单抗 血栓 狼疮 

分 类 号：R593.241[医药卫生—内科学]