高龄原发性高血压患者微血管病变对认知功能的影响  

Effect of microvascular lesions on cognitive function in advance-aged patients with primary hypertension

作　　者：杨薪[1] 钟向红[1] 李斌[1] 杨妤妤 林慈宽[1] 

机构地区：[1]广州医学院第三附属医院老年医学科,510150

出　　处：《中华老年心脑血管病杂志》2013年第7期678-680,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：广州市医药卫生科技项目(20121A011157)

摘　　要：目的探讨高龄高血压患者微血管病变与认知功能损害的关系。方法选择年龄≥80岁的原发性高血压患者75例,分为合并微血管病变组42例,无微血管病变组33例,另选同期健康体检者61例为对照组。测定尿白蛋白排泄率(UAER)、行眼底照相,用中文版简易智能状态检查量表(MMSE)对受试者进行认知功能调查,比较3组MMSE得分,并进行相关性分析。结果合并微血管病变组和无微血管病变组的MMSE总分及各组成项目得分均低于对照组(P<0.05,P<0.01)。与无微血管病变组比较,合并微血管病变组的MMSE总分、记忆力、注意力和计算力以及回忆力得分更低(P<0.05,P<0.01)。MMSE得分与UAER呈负相关(r=-0.41,P<0.01)。结论微血管病变可能是引起高龄高血压患者认知功能受损的危险因素,但对大脑各功能区的影响程度不同。Objective To study the relation between microvascular lesions and cognitive function in advance-aged patients with primary hypertension. Methods Seventy-five primary hypertension patients with their age ≥80 years,included in this study, were divided into primary hypertension group with microvascular lesion （group 1 ,n=42） and primary hypertension group without micro vascular lesion （group 2,n= 33） according to their urinary albumin excretion rate （UAER） and fundus photographic examination. Sixty-one subjects who underwent health check served as a con- trol group. Their cognitive function was tested according to the MMSE. Results The total MMSE score and each MMSE item score were lower in group 1 and group 2 than in control group （P〈0.05, P〈0.01）. The MMSE, memory, attention, calculation and recall scores were significantly lower in group 1 than in group 2 （P〈0.05,P〈0.01） but no significant difference was found in o rientation and languague between the two group. The MMSE score was negatively related with the UAER （r= 0. 41, P〈0. 01）. Conclusion Microvascular lesion may be a risk factor for cog- nitive impairement in advance aged patients with primary hypertension. However,it exerts differ ent effects on different functional areas of brain.

关 键 词：高血压 肾病 视网膜疾病 痴呆 内皮 血管 毛细血管通透性 危险因素 

分 类 号：R544.1[医药卫生—心血管疾病]