超临界CO_2流体萃取-精馏联用技术提取脱酸月见草油的工艺优选  

Optimization of Supercritical CO_2 Fluid Extraction-Fractionation Technology for One Step Deacidification of Evening Primrose Oil

作　　者：谷满仓[1] 钱亚芳[2] 

机构地区：[1]浙江中医药大学,杭州310053 [2]浙江省中医院,杭州310006

出　　处：《中国实验方剂学杂志》2013年第13期11-14,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：教育部高等学校博士学科点专项科研基金项目(20112327120008);浙江省科技厅钱江人才计划项目(2011R10068)

摘　　要：目的:优选超临界CO2流体萃取-精馏联用技术(SCFEF)提取脱酸月见草油的工艺条件。方法:以得油率和γ-亚麻酸含量为指标,采用单因素试验考察萃取压力、萃取温度、分离压力和分离温度对月见草油提取工艺的影响。比较SCFEF与超临界CO2流体萃取技术(SCFE)提取的月见草油质量差异。结果:优选的脱酸月见草油提取工艺参数为萃取压力22 MPa,萃取温度308 K,分离压力10～12 MPa,分离温度321 K,CO2用量45 kg,脱酸月见草油得率16.7%～18.1%,酸值0.85～1.21 mg KOH.g-1,所得脱酸月见草油各项理化指标均优于SCFE所得月见草油。结论:SCFEF通过将萃取、分离与纯化工序耦合,可做到一步提取脱酸月见草油。Objective： To optimize extraction technology conditions of deacidification evening primrose oil by supercritical CO2 fluid extraction-fractionation technology（SCFEF）.Method： With yield of oil and the content of γ-linolenic acid as indexes,single factor tests were adopted to investigate effect of extraction pressure,extraction temperature,separation pressure and separation temperature on extraction technology of evening primrose oil.And quality differences of evening primrose oil was compared,which were extracted by SCFEF and supercritical CO2 fluid extraction（SCFE）.Result： Optimal extraction parameters were as follows： extraction pressure 22 MPa,extraction temperature 36 ℃,separation pressure 10-12 MPa,separation temperature 48 ℃,dosage of CO2 45 kg,oil yield 16.7%-18.1%,the acid values of 0.85-1.21 mg KOH.g-1,each physical and chemical indicators of evening primrose oil from SCFEF were better than that from SCFE.Conclusion： SCFEF successfully prepared deacidified evening primrose oil by integration of extraction,separation and purification processions into one step.

关 键 词：超临界CO2流体萃取-精馏联用 月见草油 脱酸 Γ-亚麻酸 

分 类 号：R283.6[医药卫生—中药学]