宣肺化痰方标准煎剂与煮散剂药理作用对比  

Pharmacodynamic Comparison on Standardized Xuanfei Huatan Decoction and Ordinary Decoction

作　　者：戴勇 老昌辉 魏成功 黄雪君[2] 杜铁良[2] 田宁 段晨霞 

机构地区：[1]广东省中西医结合医院呼吸内科,广东佛山528000 [2]广东省中医研究所,广州510095

出　　处：《中国实验方剂学杂志》2013年第13期286-290,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广东省科技厅课题(2010B030700055)

摘　　要：目的:对比观察宣肺化痰方标准煎剂及煮散剂的药理作用。方法:大鼠分为8组,分别灌入等体积蒸馏水、急支糖浆、宣肺化痰方标准煎剂高、中、低剂量(含生药46.80,23.40,11.70 g.kg-1)、宣肺化痰方煮散剂高、中、低剂量(含生药23.40,11.70,5.85 g.kg-1),观察对小鼠毛细血管通透性的影响、对氨水致小鼠咳嗽的影响、对磷酸组胺诱发豚鼠哮喘的影响、对小鼠气管酚红排泌的影响、对慢性支气管炎大鼠超氧化物歧化酶(SOD)、丙二醛(MDA)的影响。结果:宣肺化痰方标准煎剂和煮散剂均能显著降低小鼠毛细血管通透性;延长小鼠咳嗽潜伏期和减少咳嗽次数;延长豚鼠引喘潜伏期;增加小鼠气管酚红排泌量;升高慢性支气管炎大鼠血清SOD活性,降低MDA含量。宣肺化痰方标准煎剂和煮散剂比较,两者在同剂量组级别(高、中、低)之间作用无显著性差异。结论:宣肺化痰方标准煎剂和煮散剂均有显著抗炎、止咳、平喘和化痰作用,两者作用无显著性差异。Objective： To compare the pharmacological effects between the powdered Xuanfei Huatan decoction（PXHD） and the ordinary decoction（OXHD） of the same prescription.Method： A variety of experimental models was used,and rats,mice and guinea pigs were involved in the study.Rats were divided into eight groups.The rats in different groups were given distilled water,JI-ZHI syrup,3 doses of DXHD（46.80,23.40,11.70 g.kg-1） and 3 doses of PXHD（23.40,11.70,5.85 g.kg-1） respectively.The pharmacodynamic comparison between SXHD and OXHD included the follows： ammonia-induced cough in mice,phosphorylation histamine-induced asthma in guinea pigs,tracheal secretion of phenol red in mice,capillary permeability in mice and superoside dismutas（SOD） and malondialdehyde（MDA） in rats with chronic bronchitis.Result： PXHD and OXHD both could prolong the incubation period and reduce the cough frequency in mice;extend the latent period of asthma in guinea pigs;increase the amount of tracheal secretion of phenol red;reduce capillary permeability,and increase SOD and reduce MDA in rat with chronic bronchitis.No significant difference was found between the according level of PXHD and OXHD.Conclusion： Both PXHD and OXHD have the ability of suppressing cough,asthma and phlegm,and the ability of anti-inflammatory and antioxidant.

关 键 词：宣肺化痰方 中药饮片 煮散剂 慢性支气管炎 药效 

分 类 号：R285.5[医药卫生—中药学]