护心方治疗急性心肌梗死33例  

Clinical Research on the Efficacy of Huxin Formula Therapy for Acute Myocardial Infarction

作　　者：常风云[1] 董银平[1] 

机构地区：[1]河南省鹤壁市鹤壁职业技术学院,河南鹤壁458030

出　　处：《中国实验方剂学杂志》2013年第13期323-326,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:探讨护心方对急性心肌梗死(AMI)后患者心室重构和心功能的影响。方法:66例AMI患者随机分为观察组和对照组。两组均给予临床常规治疗。观察组加用护心方口服,疗程8周。采用心脏彩超检测治疗前后心功能,并检测治疗前后血管紧张素Ⅱ(AngⅡ),转化生长因子β1(TGFβ1),超氧化物歧化酶(SOD),血清Ⅲ型前胶原氨基端肽(PⅢNP)和醛固酮(ALD)水平,并观察治疗前后气滞血瘀证积分。结果:治疗后观察组左心室舒张末期内径(LVDd),左心室舒张末期容积(LVEDV),左室收缩末期容积(LVSDV),心脏指数(CI)及左心室射血(LVEF)均较治疗前明显改善(P<0.05,P<0.01),其中LVEDV和LVEF的改善优于对照组(P<0.05);观察组治疗后AngⅡ,PⅢNP,ALD及TGFβ1均低于对照组(P<0.05,P<0.01),SOD高于对照组(P<0.05);观察组治疗后心前区刺痛、气促、心悸、胸闷、易怒及气滞血瘀均明显低于对照组(P<0.01)。结论:护心方能防治心肌梗死后心室重构,并能改善临床症状,改善心功能。Objective： To observe the impact of the Huxin formula therapy in ventricular remodeling and heart function of the patients with acute myocardial infarction.Method： Sixty-six patients were randomly divided into observation group and control group.Patients in two groups were both given conventional treatment.Huxin formula orally for 8 weeks） was given to the patients in the observation group.Echocardiography was used to check the heart function before and after treatment.Angiotensin II（Ang II）,transforming growth factor β1（TGF β1）,vascular superoxide dismutase（SOD）,serum procollagen IIIN-terminal propeptide（PIIINP） and aldosterone（ALD） levels were detected and Qi stagnancy and blood stasis syndrome score was also observed.Result： Left ventricular end-diastolic diameter（LVDd）,left ventricular end-diastolic volume（LVEDV）,left ventricular endsystolic volume（LVSDV）,cardiac index（CI） and left ventricular ejection（LVEF） of patients in the observation group were significant improved after treatment（P〈0.05,P〈0.01）,and improvement of LVEDV and LVEF were better than the patients in the control group（P〈0.05）.AngⅡ,PⅢNP,ALD and TGF β1 of the patients in the observation group were lower than patients in the control group（P〈0.05,P〈0.01）,SOD level of the patients in observation group was higher than the patients in control group,scores of precordial pain,shortness of breath,palpitation,chest tightness,irritability and Qi stagnancy and blood stasis in observation group was lower than those in the control group.Conclusion： Huxin formula therapy can prevent ventricular remodeling after myocardial infarction,it can also improve clinical symptoms and heart function.

关 键 词：急性心肌梗死 心室重构 护心方 心功能 

分 类 号：R287[医药卫生—中药学]