IL-10、TIMP-1、TNF-α在胎膜早破早产孕妇血清、羊水中的含量及意义  

Levels and significance of IL-10,TIMP-1,TNF-α in serum and amniotic fluid of preterm women with premature rupture of membranes

作　　者：叶祖峰[1] 

机构地区：[1]南华大学附属南华医院检验科,湖南衡阳421000

出　　处：《中国现代医学杂志》2013年第11期98-100,共3页China Journal of Modern Medicine

摘　　要：目的探讨白介素10(IL-10)、基质金属蛋白酶抑制因子-1(TIMP-1)、肿瘤坏死因子-α(TNF-α)在胎膜早破早产孕妇血清及羊水中的含量与胎膜早破早产的关系。方法采用酶联免疫吸附法测定胎膜早破早产孕妇(早产组)50例与正常孕妇(对照组)50例血清及羊水中的IL-10、TIMP-1、TNF-α的含量。结果早产组孕妇血清及羊水中IL-10高于对照组,而羊水TNF-α水平低于对照组(P<0.05),TIMP-1水平较对照组低(P<0.05)。早产组绒毛膜羊膜炎者血清、羊水中IL-10水平高于非绒毛膜羊膜炎组,而TIMP-1水平低于非绒毛膜羊膜炎组(P<0.05)。结论孕妇血清、羊水中IL-10、TIMP-1水平与感染引起的早产有相关关系。【Objective】 To investigate the relationship between the levels of intedeukin-10（IL-10）,Tissue Inhibitor of Metalloprotease-1（TIMP-1）,tumor necrosis factor-α（TNF-α） in serum and amniotic fluid of preterm women with premature rupture of membranes.【Methods】 The levels of IL-10,TIMP-1,TNF α in serum and anmiotic fluid were detected in 50 case with premature rupture of membranes（premature group） and 50 cases of normal pregnancy（control group） by enzyme-linked immunosorbent assay（ELISA）.【Results】The levels of IL-10 in serum and IL-10,TNF-α in anmintic fluid in premature group were significance higher than those in control group（P 0.05）,the levels of TIMP-1 in serum and anmintic fluid were significance lower than in control group（P 0.05）.In premature group,the levels of IL-10 in serum and anmiotic fluid of women with chorioamnionitis were significantly higher than those of women without chorioamnionifis,while the levels of TIMP-1 in serum and anmiotic fluid of women with chorioamnionitis were significantly lower than those of women without chorioamnionifis（P 0.05）.【Conclusion】 The levels of IL-10,TNF-α in serum and amniofic fluid of the pregnant women are associated with the onset of preterm labor coused by infection.

关 键 词：IL-10 TIMP-1 TNF-Α 胎膜早破 早产 

分 类 号：R714.433[医药卫生—妇产科学]