急性冠脉综合征患者血清HsCRP和IFN-γ的检测及意义  

The analysis of level High-sensitivity C-reactive protein and Interferon-γ for acute coronary syndrome(ACS) patients

作　　者：肖涛[1] 丘世飏[2] 王琰[3] 

机构地区：[1]中南大学湘雅三医院急诊科,湖南长沙410013 [2]中南大学湘雅医院检验科,湖南长沙410008 [3]江苏省人民医院,江苏南京210029

出　　处：《中国现代医学杂志》2013年第12期34-37,共4页China Journal of Modern Medicine

摘　　要：目的探讨急性冠脉综合征(ACS)患者血清超敏C反应蛋白(HsCRP)和干扰素γ(IFN-γ)水平变化,为临床判断冠状动脉粥样硬化(AS)斑块性质提供理论依据。方法选择行冠状动脉造影患者76例,为ACS组其中急性心肌梗死(AMI)28例,不稳定型心绞痛(UAP)48例;正常对照组20例。分别应用酶联免疫吸附实验(ELISA法)检测血清IFN-γ水平和乳胶增强免疫比浊法检测血清HsCRP。结果 ACS患者血清HsCRP(9.55±6.94)mg/L和IFN-γ(1071.86±496.19)pg/mL水平明显高于正常对照组HsCRP(0.96±0.69)mg/L和IFN-γ(458.62±116.48)pg/mL(P<0.05);AMI组患者血清HsCRP(15.60±4.17)mg/L和IFN-γ(1442.15±649.85)pg/mL水平明显高于UAP组HsCRP(6.01±5.68)mg/L和IFN-γ(855.86±158.88)pg/mL(P<0.05)。结论 IFN-γ和HsCRP血清水平可以作为判断AS斑块不稳定性的指标,也参与AS斑块由静止状态向活动状态转化并导致斑块破裂的过程。【Objective】 To study high sensitive C reactive protein（HsCRP） and interferon（IFN-γ） level in acute coronary syndrome（ACS） patients＇ serum,for the clinical diagnosis of coronary atherosclerosis（AS） plaque and provide a theoretical basis.【Methods】 Patients received coronary angiography 76 Cases of ACS divided into group acute myocardial infarction（AMI） 28 cases and unstable angina pectoris（UAP） 48 cases,and normal controls group 20 cases.Application of enzyme linked immunosorbent assay（ELISA） for detection of serum HsCRP and IFN-γ levels.【Results】 The ACS patients with serum HsCRP and IFN-γ levels were significantly higher than those in normal control group（P 0.05）;group AMI patients with serum HsCRP and IFN-γ levels were significantly higher than in group UAP（P 0.05）.【Conclusion】 IFN-γ and HsCRP serum levels can be used as a AS plaque instability index,are also involved in AS plaque from stationary state to active state transformation and leading to plaque rupture process.

关 键 词：干扰素Γ 超敏C反应蛋白 急性冠脉综合征 

分 类 号：R543.3[医药卫生—心血管疾病]