慢性充血性心力衰竭患者血清syndecan-4水平及临床意义  

Changes and clinical significance of serum level of syndecan-4 protein in patients with chronic congestive heart failure

作　　者：马晓玲[1] 欧阳平[1] 张志能[1] 赖文岩[1] 许顶立[1] 

机构地区：[1]南方医科大学南方医院心血管内科,广东广州510515

出　　处：《细胞与分子免疫学杂志》2013年第8期866-869,共4页Chinese Journal of Cellular and Molecular Immunology

基　　金：广州市科信局基金项目(2010U1-E00531-11)

摘　　要：目的探讨慢性充血性心力衰竭(CHF)患者血清中syndecan-4浓度变化与CHF NYHA心功能分级及超声心动图指标变化的关系。方法选择40名CHF患者和40位健康人;用ELISA检测外周血中的syndecan-4浓度,超声心动图测定左室射血分数(LVEF)、左室短轴缩短率(FS)、左室舒张末期直径、左室收缩末期直径、左室舒张末期容积、左室收缩末期容积等数值;观察syndecan-4蛋白水平与CHF NYHA心功能分级及超声心动图指标变化的相关性。结果 CHF组患者血清syndecan-4水平均较对照组显著升高(P<0.01),且随CHF NYHA心功能分级增加而进行性升高;相关分析显示血清syndecan-4蛋白水平与左室射血分数及左室短轴缩短率分别存在显著负相关(P<0.05),与左室舒张末期直径,左室收缩末期直径,左室舒张末期容积,左室收缩末期容积分别存在显著正相关(P<0.05)。结论 CHF患者血清syndecan-4浓度显著升高,并与NYHA心功能分级密切相关,血清syndecan-4水平与左室心功能超声参数存在显著相关性,对CHF患者具有一定的诊断价值。Objective To detect serum level of syndecan-4 protein in patients with chronic congestive heart failure （CHF） and investigate its correlation with New York Heart Association （NYHA） class and echocardiographic parameters. Methods The concentration of serum syndecan-4 protein was measured by enzyme-linked immunosorbent assay （ELISA） in 40 patients with CHF and 40 healthy controls （ NCD）, respectively. The parameters such as left ventricle ejection fraction （ LVEF）, fraction shortening （FS）, left ventricle end-diastolic diameter （ LVDd）, left ventricle end-systolic diameter （ LVDs）, left ventricle end-diastolic volume （LVEDV） and left ventricle end-systolic volume （LVESV） were detected by echocardio-graphy in 40 patients of CHF. Meanwhile, the patients＇ cardiac function was graded according to NYHA class. Results The levels of serum syndecan-4 protein significantly increased in CHF group as compared with control group （P〈0.01）. In CHF group, as the increased grading of NYHA cardiac function, the levels of serum syndecan-4 protein significantly increased （P 〈 0.05）. The more upgraded the NYHA grading, the higher level of serum syndecan-4 protein. In bivariate correlations analysis showed that the level of serum syndecan-4 protein was significantly negatively correlated with LVEF and FS （ P 〈 0.05） and was significantly positively correlated with LVDd, LVDs, LVEDV and LVESV, respectively （ P 〈 0.05）. Conclusion Serum syndecan-4 concentration significantly increased in CHF patients, and it was closely correlated with NYHA class and left ventricle function parameters, so the level of serum syndecan-4 protein may have an important value in detection and surveillance of CHF.

关 键 词：充血性心力衰竭 SYNDECAN-4 GALECTIN-3 心肌重塑 心肌肥厚 

分 类 号：R541.61[医药卫生—心血管疾病] R392-33[医药卫生—内科学]