12种广东地产清热解毒药的抗内毒素作用研究  

Experimental Studies on Anti-LPS Effects of 12 Guangdong Native Heat-clearing and Detoxicating Herbs

作　　者：范文昌[1] 梅全喜[2] 刘亚娟[1] 王书芹[2] 

机构地区：[1]广东食品药品职业学院,广东广州510520 [2]广州中医药大学附属中山医院,广东中山528400

出　　处：《今日药学》2013年第5期261-263,共3页Pharmacy Today

基　　金：广东省中医药局科技基金资助项目(编号:2011083);中山市科技计划资助项目(编号:20113A007)

摘　　要：目的观察12种广东地产清热解毒药水提取物在同一剂量(16 g/kg)的抗内毒素作用,为寻求有效中药防治内毒素性多器官功能衰竭提供可靠的实验依据。方法小鼠连续7 d,灌胃16 g/kg,7 d后腹腔注射内毒素(LPS,O55B5),观察小鼠生存率和肺、肝的病理变化。结果三丫苦、水杨梅组小鼠生存率明显较高(P<0.05),组织学观察显示三丫苦、水杨梅组小鼠肺、肝的病理变化明显减轻。结论部分广东清热解毒药能防治内毒素引起的多器官损伤,提高内毒素血症小鼠生存率。Objective To compare the anti-LPS effcts of the water-solubility extract of 12 Guangdong heat-clearing and detoxicating herbs at the same dose（16 g/kg）,and to provide the development basis for preventing LPS-induced multiple organ injury.Methods LPS was injected intraperitoneally after 7 d gastric lavage at the dose of 16 g/kg.The survival rates and pathological changes of rats＇ lung and liver in each group were observed.Results Survival rates in rats of Melicope pteleifolia（champ.ex Benth.） T.G.Hartley and Adina rubella Hance groups were higher than that in LPS group.The pathological changes of lung and liver of rats in Melicope pteleifolia（champ.ex Benth.） T.G.Hartley and Adina rubella Hance groups were significantly relived.Conclusion The results showed that some heat-clearing and detoxicating herbs of Guangdong have protective effect on LPS induced multiple organ injury.

关 键 词：清热解毒 内毒素 生存率 多器官功能障碍 

分 类 号：R285[医药卫生—中药学]