High-sensitive and temperature-self-calibrated tilted fiber grating biological sensing probe  

作　　者：LIU Fu GUO Tuan LIU JianGuo ZHU XiaoYang LIU Yu GUAN BaiOu ALBERT Jacques 

机构地区：[1]Institute of Photonics Technology, Jinan University [2]Institute of Semiconductors, Chinese Academy of Sciences [3]Department of Biochemistry, Medical School, Jinan University [4]Department of Electronics, Carleton University

出　　处：《Chinese Science Bulletin》2013年第21期2611-2615,共5页

基　　金：supported by the National Natural Science Foundation of China (61205080, 61235005 and 61036012);the National Innovation Fund for Technology (2C26214405312);Guangdong Natural Science Foundation of China (S201101000163 and S2012010008385);the Specialized Research Fund for the Doctoral Program of Higher Education of China(20114401120006);the Pearl River Scholar for Distinguished Young Scientist (2011J2200014)

摘　　要：High sensitivity biological sample measurement has been achieved by using a 10° tilted fiber Bragg grating sensing probe. Human acute leukemia cells with different intracellular densities were clearly discriminated by identifying their slight refraction index (RI) perturbations in the range from 1.3342 to 1.3344, combining with a temperature self-calibration property. We studied the relationship between the intracellular density of cells (S50 and S60) and their RIs, the experimental results provide a potential way to verify the hypothesis for "density alteration in non-physiological cells (DANCE)".High sensitivity biological sample measurement has been achieved by using a 10° tilted fiber Bragg grating sensing probe. Human acute leukemia cells with different intracellular densities were clearly discriminated by identifying their slight refraction index （RI） perturbations in the range from 1.3342 to 1.3344, combining with a temperature self-calibration property. We studied the rela- tionship between the intracellular density of cells （S50 and S60） and their RIs, the experimental results provide a potential way to verify the hypothesis for ＂density alteration in non-physiological cells （DANCE）＂.

关 键 词：传感探头 光纤光栅 高灵敏度 自校准 生物 温度 细胞密度 白血病细胞 

分 类 号：TN253[电子电信—物理电子学] TP212.3[自动化与计算机技术—检测技术与自动化装置]