不稳定型心绞痛患者血清血管生成因子质量浓度的变化  

Changes in serum concentrations of angiogenic factors in patients with unstable angina pectoris

作　　者：桂春[1] 堵芳[1] 农勤玲[1] 连滨静[1] 朱立光[1] 

机构地区：[1]广西医科大学第一附属医院心内科,南宁530021

出　　处：《中华急诊医学杂志》2013年第7期712-715,共4页Chinese Journal of Emergency Medicine

基　　金：国家自然科学基金（81160021）;广西自然科学基金（2011GXNSFA018223）

摘　　要：目的检测不稳定型心绞痛患者血清中血管生成因子质量浓度的变化。方法选择57例在广西医科大学第一附属医院住院并确诊为不稳定型心绞痛的患者为研究组，研究组又分为糖尿病亚组（23例）和非糖尿病亚组（34例）。排除标准为病情复杂、伴有其他器官功能损害、外周血管病变、脑梗死和近期有感染的患者。对照组为在本院体检年龄相配的健康人，共36例。收集血清，然后使用蛋白芯片检测血清中血管内皮生长因子（VEGF）、血管形成蛋白一1（angiopoietin．1）、血管形成蛋白-2（angiopoietin-2）、血管生成素（angiogenin）、血管抑素（angiostatin）、碱性成纤维细胞生长因子（brGr）和血小板衍生生长因子BB（PDGF—BB）质量浓度，使用SPSS13．0软件对数据进行成组设计资料的t检验。结果在不稳定型心绞痛患者血清中VEGF和angiopoietin-2质量浓度较正常对照组显著增高（均P〈0．01），而angiogenin、angiopoietin-1、angiostatin、bFGF和PDGF—BB两组之间比较，差异无统计学意义。在糖尿病亚组和非糖尿病亚组之间比较，7个血管生成因子的血清浓度比较差异无统计学意义。结论不稳定型心绞痛患者血清中VEGF和angiopoietin-2浓度明显增高，糖尿病并不影响这种变化。Objective To detect the changes in serum concentrations of angiogenic factors in patients with unstable angina pectoris. Methods A total of 57 patients with unstable angina pectoris were eligible for study and divided into diabetes group （ n = 23 ） and non-diabetes group （ n = 34 ）. Exclusion criteria included complicated diseases, symptomatic peripheral vascular diseases, renal or liver diseases, cerebral embolism and evidence of ongoing infection. Another 36 age-matched healthy subjects from medical examination center were enrolled as control group. Serum samples were collected, and serum concentrations of vascular endothelial growth factor （ VEGF ）, angiopoietin-1, angiopoietin-2, angiogenin, angiostatin, basic fibroblast growth factor （bFGF） and platelet-derived growth faetor-BB （PDGF-BB） were measured by using cytokine array technology： The data were analyzed by independent-samples t test with the SPSS 13.0 statistic software package. Results Compared with the control group, the serum concentrations of VEGF and angiopoietin-2 were significantly increased in patients with unstable angina pectoris （ both P 〈 0. O1 ）. Whereas, no significant differences in serum concentrations of angiogenin, angiopoietin-1, angiostatin, bFGF, and PDGF-BB were detected between control group and patient groups. There were no significant differences in serum concentrations of above all 7 biomarkers between diabetes group and non-diabetes group. Conclusions Serum concentrations of VEGF and angiopoietin-2 were increased in patients with unstable angina pectoris, and diabetes didn＇t affect the increases in serum concentrations of VEGF and angiopoietin2 caused by unstable angina pectoris.

关 键 词：不稳定型心绞痛 糖尿病 血管生成因子 血管内皮生长因子 血管形成蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]