磁共振无对比剂选择性门脉成像的技术优化  

Parameter Optimization for Non-contrast-enhanced Selective Magnetic Resonance Portography Imaging

作　　者：王萱[1] 杜顺达[2] 薛华丹[1] 金征宇[1] 杨盈韵[1] 刘梦雨[1] 赵欣智[1] 孙照勇[1] 金阳[1] 孙宏毅[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院放射科,北京100730 [2]中国医学科学院北京协和医学院北京协和医院肝脏外科,北京100730

出　　处：《中国医学科学院学报》2013年第3期299-304,共6页Acta Academiae Medicinae Sinicae

摘　　要：目的评价利用时间-空间标记反转脉冲(T-SLIP)结合3D真实稳态自由进动序列(SSFP)技术进行无对比剂增强的选择性磁共振门脉成像的应用价值及参数优化。方法以13名健康志愿者为研究对象,在1.5T磁共振设备上采用结合了T-SLIP脉冲的3D True SSFP序列进行门脉减影图像,每名受检者的扫描方案包括反转时间(TI)分别为1300 ms(A组)、1100 ms(B组)、900 ms(C组)及700 ms(D组)的4组门脉成像序列。定量比较肝左、右叶和门脉主干、左支、右支及肝段分支(P4、P6、P8)的信号强度,并比较门脉各血管的相对信号强度。采用4分法定性评价门脉系统的成像质量,One-Way ANOVA分析和LSD检验对定量数据进行检验,Friedman秩检验对定性数据进行检验。结果 13例检查共52个序列均成功实现选择性门脉成像。C、D组的肝左叶信号明显高于于A、B组(C组与A、B组:P=0.004、0.011;D组与A、B组:P=0.001、0.004)。C、D组门脉左支的相对信号强度则较A、B组明显降低(C组与A、B组:P=0.015、0.015;D组与A、B组:P=0.000、0.000)。D组门脉主干的相对信号强度较A(P=0.000)、B(P=0.000)、C组(P=0.019)明显减低。各段分支的相对信号强度差异没有统计学意义(P>0.05)。门脉主干及各分支在图像质量评分上差异没有统计学意义(P>0.05)。结论磁共振无对比剂门脉减影成像技术可行性好,选择TI为1300及1100ms可有较好的成像效果。Objective To evaluate subtraction images acquired with 3D true steady-state free-preces- sion （SSFP） sequence combined with time-spatial labeling inversion pulse （T-SLIP） for selective and non-con- trast-enhanced （non-CE） visualization of the portal venous system, and explore the optimization of this proto- col. Methods Totally 13 healthy volunteers were recruited. Respiratory-triggered 3D true SSFP sequences on a 1.5T MRI system combined with T-SLIP placed on the spleen and mesenteric area were performed. The portographic images were generated from the subtraction between the pulse on and off images. According to the difference in inversion time （TI） of T-SLIP, four image groups： group A （TI of 1300 ms）, group B （TI of 1100 ms）, group C （ TI of 900 ms） and group D （TI of 700 ms）, were assigned and compared to detect the optimal TI for portography. For quantitative analysis, the signal intensity （SI） of left and right liver lobe, the large vessels as main, right and left portal vein （MPV, RPV and LPV, respectively） and small vessels as branches of segments four （P4）, six （P6） and eight （P8） were measured. The relative SI of MPV, RPV and LPV, as well as P4, P6 and P8 were also compared. For qualitative evaluation, the quality score of visualization was also evaluated using a 4-point scale. One-Way ANOVA and LSD test were used for comparison of quantitative data, and Friedman signed rank test was used for comparison of qualitative scores. Results In 52 sequences of 13 volunteers, the se- lective visualization of the portal vein was all successfully conducted. Quantitative evaluation showed significant increased SI at the left lobe between C and D groups and A and B groups （ comparison of group C to group A and B ： P = 0. 004, 0. O11 ; comparison of group D to group A and B ： P = 0. 001, 0. 004）, while relative SI of LPV of groups C and D were lower than groups A and B （comparison of group C to group A and B： P =0. 015, 0. 015; comparison of group D t

关 键 词：磁共振血管造影 门静脉 无对比剂增强 时间 空间标记反转脉冲 反转时间 

分 类 号：R814.42[医药卫生—影像医学与核医学]