西洋参抗癌研究进展——以结直肠癌为研究范例  

Progress in anti-cancer research of American ginseng:with an example of colorectal cancer

作　　者：喻春皓[1,2,3] 王冲之[1,2] 袁钧苏[1,2,4] 

机构地区：[1]美国芝加哥大学唐氏植物药研究中心,伊利诺伊州芝加哥60637 [2]美国芝加哥大学麻醉与重症监护系,伊利诺伊州芝加哥60637 [3]淮阴工学院生命科学与化学工程学院,江苏淮安223003 [4]美国芝加哥大学临床药理与药物基因组学委员会,伊利诺伊州芝加哥60637

出　　处：《药学学报》2013年第7期986-992,共7页Acta Pharmaceutica Sinica

基　　金：美国NIH/NCCAM项目(P01 AT 004418;K01 AT 005362);江苏省自然科学基金项目(BK2008194);2011年江苏省优秀中青年教师及校长境外研修计划项目

摘　　要：癌症是由细胞生长调控机制失控而引起的多种疾病群。目前使用的化疗药物许多来源于植物,因此从中草药及食源植物中筛选新的抗肿瘤药物是一个有效途径,包括先导化合物的发现及相应化疗衍生物的开发。本文主要以人参属药材抗结直肠癌为例,对西洋参抗癌研究进展加以综述。西洋参除具有潜在抗癌作用外,在癌症治疗中常被用作为辅助药物来缓解因化疗药物引起的毒副作用。研究表明,高温炮制西洋参及其人参皂苷的肠道菌群代谢产物可显著增加抗癌活性,揭示化学物质与构效关系。源于中草药成分及临床研究数据将有助于开发新的抗癌药物。Cancer is a group of various diseases, all of which involve unregulated cell growth. Many currently used chemotherapeutic drugs are derived from botanicals. Thus, searching botanical sources for novel oncology medications, including identifying the lead compounds and their derivatives for chemoprevention, is an essential step in advancing cancer therapeutics. This article mainly focuses on the data from our previous American ginseng anti-colon cancer studies. In addition to the potential role of American ginseng on cancer, the herb as an adjuvant for cancer treatment is presented, including describing the attenuation of adverse events induced by chemotherapeutic agents and increasing of quality of cancer patient life. Since heat-treated American ginseng and ginsenoside gut microbiome metabolites showed significant increases in cancer chemopreventive effects, active constituents of the steamed herb and their gut metabolites should be clearly identified, and the structure-activity relationship should be further explored. Data obtained from herbal medicine studies and clinical trials will help develop useful anticancer agents.

关 键 词：西洋参 结直肠癌 化疗 不良反应 肠道菌群 

分 类 号：R285[医药卫生—中药学]