丹参药用模式植物研究探讨  

Salvia miltiorrhiza as medicinal model plant

作　　者：宋经元[1] 罗红梅[1] 李春芳[1] 孙超[1] 徐江[1] 陈士林[1,2] 

机构地区：[1]中国医学科学院北京协和医学院药用植物研究所,北京100193 [2]中国中医科学院中药研究所,北京100700

出　　处：《药学学报》2013年第7期1099-1106,共8页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金重点项目(81130069);国家科技支撑计划资助项目(2012BAI29B01);教育部长江学者与创新团队发展计划资助项目(IRT1150)

摘　　要：药用模式生物研究体系是推动中药现代化的核心技术支撑之一,本文概述丹参药用模式植物研究进展,评述了丹参基因组、生活史、遗传转化体系的特征,及丹参基因组学、转录组学等研究的近期重要进展,探讨确立丹参作为药用模式植物的生物学基础。文章进一步阐述药用模式植物在中药材活性成分生物合成与遗传调控、中药材质量与生态环境关系、优良品种选育等方面的应用前景,显示构建丹参突变体库、绘制基因组精细图、强化功能基因挖掘对开展药用模式植物研究的重要作用。借助现代生命科学研究的最新成果,加速建立丹参药用模式植物研究体系,对促进国际传统药物学研究的发展,满足国际国内对创新药物研究的迫切需求具有重要意义。Research on medicinal model organism is one of the core technologies to promote the modernization of traditional Chinese medicine （TCM）. The research progress of Salvia miltiorrhiza as medicinal model plant is summarized in this paper. The genome of S. miltiorrhiza is small and its life cycle is short, as well as this plant can be stably genetically transformed. Because S. miltiorrhiza possesses the important medicinal and economic values, recently the transcriptome and genome of S. miltiorrhiza have been significantly recovered. The research prospect of S. miltiorrhiza as medicinal model plant in TCM was discussed, including biosynthesis of active components and their genetic regulation, relationship between quality of TCM and ecological environments, and selective breeding of good quality lines. Furthermore, as medicinal model plant, the construction of mutant library for S. miltiorrhiza, the genome map with high quality, and the functional genome should be investigated. Accompanying modern investigation of life sciences, the platform for medicinal model plant, S. miltiorrhiza, will be promoted to be established. It is important to develop the ethnopharmacology and new drugs around the world.

关 键 词：丹参 药用模式植物 传统药物学 生物合成 

分 类 号：R931[医药卫生—生药学]