粉体改性技术用于亲水性青黛饮片的制备及其原理  

Powder modification technology used for the preparation of the hydrophilic decoction pieces of Indigo Naturalis and the modification principle

作　　者：张定堃[1] 林俊芝 刘剑云[1] 秦春凤[1] 郭治平 韩丽[1] 杨明[3] 

机构地区：[1]成都中医药大学,中药资源系统研究与开发利用省部共建国家重点实验室培育基地,四川成都611137 [2]四川厚德医药科技有限公司,四川成都611731 [3]江西中医学院,现代中药制剂教育部重点实验室,江西南昌330004

出　　处：《药学学报》2013年第7期1148-1155,共8页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(30973952);四川省重大产业技术创新专项项目(2011ZY00299)

摘　　要：普通青黛饮片(normal decoction pieces,NDP)亲水性差,不适于汤剂给药,不能满足临床使用的需要。本文运用粉体改性技术,在振动磨中加入适量的青黛与乙醇共研磨,制备了亲水性饮片(hydrophilic decoctionpieces,HDP)。与普通饮片、微粉饮片(ultrafine decoction pieces,UDP)的性质对比发现:微粉饮片的亲水性略有改善,亲水性饮片接触角显著降低,亲水性明显增强。3批次来源的青黛被分别制成亲水性饮片,其接触角无显著性差异,说明原料的批次差异不是影响亲水性变化的主要因素。亲水性饮片的粒径分布、比表面积及微观形态介于普通饮片与微粉饮片之间;3种饮片中靛蓝和靛玉红含量一致,其中5种难溶性无机物种类一致。结果说明,物理状态、有机物或无机物的质与量变化不是引起亲水性变化的主要因素。通过对红外光谱中3 356与1 461cm 1处特征峰的识别,可以鉴别亲水性青黛中-OH、-CH2-、-CH3的存在,通过气相色谱法测定亲水性青黛中乙醇含量为0.67%,加热处理发现亲水性饮片在40℃条件下储存相对稳定。上述研究提示,乙醇是引起青黛亲水性变化的主要因素,青黛表面靛蓝等有机物与乙醇形成的分子间作用力使乙醇固定于青黛表面,可能是青黛实现亲水性改性的基本原理。The hydrophilicity of the normal decoction pieces （NDP） of Indigo Naturalis is not good, therefore, it is not suit for decoctions. In this paper, powder modification technology is used and some NDP and alcohol are ground together in the vibromill to prepare the hydrophilic decoction pieces （HDP） of Indigo Naturalis. Initially, the properties of NDP, ultrafine decoction pieces （UDP） and HDP are compared, the hydrophilicity of UDP was promoted slightly, that of HDP is promoted dramatically. Then, three batches of Indigo Naturalis are prepared to HDP separately, but there is no obvious difference in the contact angle. Furthermore, the size distribution, surface area and micro-shape of HDP are bigger than that of UDP and smaller than NDP. The contents of indigo and indirubin in three decoction pieces are the same, as well as the species of inorganic substance, although there is a little difference in the proportion of five inorganic substances. The fact suggests the change of physical state and the qualitative and quantitative change of organism and inorganic substances are not the main factors to influence the hydrophilicity. In addition, hydroxyl, methylene and methyl can be identified at the wavenumber of 3 356 cm-1 and 1 461 cm-1 in infrared spectrum; the content of alcohol in HDP is 0.67% measured by gas chromatogram. The stability of HDP in the heating condition is studied, the fact suggests the hydrophilic effect of HDP at 40℃ is relatively stable. All above research suggests that the alcohol is the main factor to influence the hydrophilicity and maybe the intermolecular force which fixed alcohol molecule on the surface of Indigo Naturalis is the basic principle to produce the hydrophilicity.

关 键 词：青黛 乙醇 亲水性 粉体改性 接触角 

分 类 号：R943[医药卫生—药剂学]