射频热凝固治疗无排卵型功能失调性子宫出血预后差异性的Meta分析  

The differences in the prognosis of radiofrequency thermal coagulation therapy for anovulatory dysfunctional uterine bleeding:Meta-analysis

作　　者：余锦芬[1] 毛红梅[1] 

机构地区：[1]湖北省十堰市妇幼保健院妇科,十堰442000

出　　处：《现代妇产科进展》2013年第6期457-460,共4页Progress in Obstetrics and Gynecology

摘　　要：目的:评价射频热凝固(RF)治疗无排卵型功能失调性子宫出血(ADUB)的疗效。方法:检索2002年9月1日至2012年9月1日Cochrane图书馆、MEDLINE、PubMed、Web of Science、万方数据库(CECDB)、维普中文科技期刊全文数据库(CQVIP)、中国学术期刊全文数据库(CNKI),提取纳入文献的资料,并严格评价文献质量。应用Review Manager 5.0软件对符合质量标准的随机对照试验(RCT)进行Meta分析。结果:最终纳入6篇RCT研究,共计313例患者,其中治疗组(使用RF)156例,对照组(使用宫腔镜内膜电切除术、微波内膜去除术)157例。两组患者均进行常规口服孕激素和对症支持治疗。Meta分析结果显示:与对照组比较,治疗组治疗3个月后PBAC(月经量评分)显著下降(WMD为-22.70,95%CI为-24.65～-20.75)、痛经症状显著缓解(RR=0.62,95%CI为0.40～0.95)、Hb含量显著上升(WMD为23.83,95%CI为21.47～26.19),差异均有统计学意义。结论:RF较宫腔镜内膜电切除术和微波内膜去除术,能显著提高ADUB的疗效。Objective：To evaluate the efficacy of radiofrequency（RF） thermal coagulation therapy on anovulatory dysfunctional uterine bleeding（ADUB）.Method：Data was retrieved from the database of Cochrane Library、MEDLINE、PubMed、Web of Science、CECDB、CQVIP、CNKI from Sep.2002 to Sep.2012.The meta-analysis was conducted on standard RCT using Review Manager 5.0.Results：Six RCT studies with 313 patients were included in our study.The treatment group（treated with radiofrequency thermal coagulation） comprised of 156 cases,and the control group（treated with hysteroscopic endometrial electrical excision microwave endometrial ablation） of 157 cases,both were given conventional oral progesterone and symptomatic treatment.Meta-analysis results showed that there were significant differences in the treatment group and control group,PBAC significantly decreased,dysmenorrhea symptoms significantly alleviated,hemoglobin content significantly increasedafter 3 months of treatment.Conclusion：Compared to the control group,radiofrequency thermal coagulation can significantly improve the efficacy of dysfunctional uterine bleeding.

关 键 词：射频热凝固 无排卵型功能失调性子宫出血 月经量评分 META分析 

分 类 号：R711.51[医药卫生—妇产科学]