银杏内酯C对正常大鼠在体心功能的影响  

Effect of Ginkgolide C in cardiac function of rats in the body

作　　者：赵婷[1] 苏中平[1] 朱莉莉[1] 许茂春[1] 周典[1] 董薇[1] 郝艳玲[1] 

机构地区：[1]徐州医学院,江苏徐州221004

出　　处：《临床医药实践》2013年第7期524-526,共3页Proceeding of Clinical Medicine

基　　金：江苏省大学生实践创新训练计划省级项目(项目编号:2012JSSPITP1857)

摘　　要：目的:探讨银杏内酯C(Ginkgolide C,GC)对正常大鼠在体心功能的影响。方法:正常大鼠麻醉后,用连接压力换能器的插管经右侧颈总动脉逆行插入左心室,并用PowerLab生物信号采集系统检测心功能。经颈静脉分别给予生理盐水、1‰的二甲基亚砜(DMSO)、100μmol/L的GC、1 000μmol/L的GC各1mL,通过连续记录左心室收缩压(LVSP)、左心室舒张末压(LVEDP)、心脏收缩期左心室内压上升的最大变化速率(+dp/dtmax)、舒张期左心室内压下降的最大变化速率(-dp/dtmax)和心率(HR)等心功能指标来测定给药前后心功能的变化。结果:与正常条件下相比,给予浓度为100μmol/L的GC 1mL后,对心功能各指标均无明显影响;给予浓度为1 000μmol/L的GC 1mL后对正常大鼠心脏产生正性肌力的作用,能明显增强左心室内压差(△LVP)、+dp/dtmax、-dp/dtmax等心功能指标,但对HR无明显影响。结论:银杏内酯C能增加左心室内压力差,增强心肌的收缩和舒张功能,而对心率没有影响,对心脏具有一定程度的正性肌力作用。ObjectiveTo study the effect of Ginkgolide C（GC） in cardiac function of rats in the body.Methods ： Normal rats after anesthetized,inserted the intubate which connecting the pressure transducer into left ventricular from the right common carotid artery,then detected the cardiac function by the PowerLab biological signal acquisition system.Gave each of saline,1‰dimethyl sulfoxide（DMSO）,100 μ mol / L GC,1 000 μ mol / L GC 1ml from the jugular vein,detected the cardiac function before and after administration by continuous recording the left ventricular systolic pressure（LVSP）,left ventricular end diastolic pressure（LVEDP）,the maximal rate of pressure increase in systole phase（＋dp / dtmax）,maximal rate of pressure decrease in diastole phase（-dp / dtmax） and heart rate（HR）.Results ： Compared with normal conditions,when given 100 μ mol / L GC,there are no significant effect on cardiac function;when given 1 000 μ mol / L GC,it showed inotropic activity by increasing △LVP,＋dp / dtmax,-dp / dtmax significantly,but had no significant effect on HR.Conclution ： Ginkgolide C can increase△LVP significantly,enhances the myocardial systolic and diastolic function of rats,but has no significant effect on HR while it shows inotropic activity.

关 键 词：银杏内酯C 在体 心功能 正性肌力 

分 类 号：R285.5[医药卫生—中药学]