益生菌对抗生素诱导的大鼠腹泻肠道菌群的影响作用  

Effects of Probiotics on the Intestinal Flora of Diarrhea Rats Induced by Antibiotics

作　　者：武香玉[1] 徐海燕[1] 辛国芹[1] 曹银生[1] 汪孟娟[1] 谷巍[1] 

机构地区：[1]山东宝来利来生物工程股份有限公司,山东泰安271000

出　　处：《畜牧与饲料科学》2013年第6期22-23,27,共3页Animal Husbandry and Feed Science

摘　　要：[目的]观察益生菌对抗生素诱导的大鼠腹泻肠道菌群的影响作用。[方法]采用头孢曲松构建大鼠腹泻模型。大鼠幼鼠分组,除对照组外灌胃头孢曲松4d建立大鼠腹泻模型,后以益生菌制剂治疗7d,检测大鼠各项指标情况。[结果]益生菌治疗1周后,大鼠幼鼠体重有所回升,乳杆菌和双歧杆菌等恢复到对照水平,并且优于自然恢复组。[结论]益生菌可以改善抗生素诱导的大鼠腹泻,对菌群失调有一定的作用。[Objective] The research aimed to evaluate the effects of probiotics on intestinal flora of diarrhea rats induced by antibiotic. [Method] The diarrhea model of rats was build by cefiriaxone. The rats were divided into groups. Except control group, rats in other groups were injected by gavage with ceftriaxone for four clays to build the diarrhea model of rats. Then rats were treated with probiotic preparation for 7 days. The indicators of rats were detected. [ Result ] After they were treated one week, the body weight of young rats rose up. And lactobaeillus and bifidobacterium recovered to control level, but they were still better than natural recovery group. [Conclusion] The probiotics could improve antibiotic-induced diarrhea in rats and have certain role for flora imbalance.

关 键 词：益生菌 抗生素 腹泻 肠道菌群 

分 类 号：R96[医药卫生—药理学] S816.7[医药卫生—药学]