胱抑素C、同型半胱氨酸和糖化血红蛋白联合检测在糖尿病早期肾脏损害的临床意义  

The clinical significance of joint detection of cystatin C,homocysteine and glycated hemoglobin in early diabetic renal damage

作　　者：朱武[1] 谢万华[1] 刘玉泉[1] 邓向海[1] 汪涛[1] 李琳 

机构地区：[1]安康市中医院检验科,陕西安康725000 [2]安康市中医院内分泌科,陕西安康725000

出　　处：《国际检验医学杂志》2013年第11期1386-1387,共2页International Journal of Laboratory Medicine

摘　　要：目的通过联合检测糖尿病患者胱抑素C(CysC)、同型半胱氨酸(Hcy)和糖化血红蛋白(HbA1c)3项指标,探讨其在预防、诊断及治疗糖尿病早期肾脏损害的临床意义。方法收集糖尿病早期肾病组62例,单纯糖尿病组120例,健康对照组50例,运用乳胶颗粒免疫比浊法检测血清CysC,循环酶法检测Hcy,离子交换高效液相色谱法检测HbA1c,并对所测结果进行统计分析。结果糖尿病早期肾病组3项指标均高于单纯糖尿病组和健康对照组,差异有统计学意义(P<0.05);单纯糖尿病组和健康对照组相比,Cys C、HbA1c差异有统计学意义(P<0.05);但Hcy差异无统计学意义(P>0.05)。结论 Cys C、Hcy和HbA1c 3项指标联合检测对糖尿病早期肾脏损害的诊断、治疗和病情监测有重要意义。Objective To explore the clinical significance of joint detection of Cystatin-C（Cys C）,homocysteine（Hcy） and glycated hemoglobin in diagnosis,monitoring,prevention of early renal injury in patients with diabetes mellitus.Methods 62 patients with early diabetic renal damage were in early diabetic renal damage group and 120 patients with simple diabetes mellitus were in simple diabetes mellitus group.50 healthy persons were the control group.Using immunoturbidimetry to detect the serum level of Cys C,circulating enzymatic method to detect the Hcy,and ion exchange high performance liquid chromatography method to detect the level of HbA1c.Results There were statistically significant differences in the level of Cys C,homocysteine and glycated hemoglobin between early diabetic renal damage group and the other two groups（P0.05）.There were statistically significant differences in the level of Cys C and glycated hemoglobin between simple diabetes mellitus group and healthy control group（P0.05）;while the level of Hcy was just on the opposite（P0.05）.Conclusion It is important for patients with diabetes mellitus to detect the Cys C,homocysteine and glycated Hemoglobin in diagnosis,monitoring,prevention of early renal injury.

关 键 词：糖尿病肾病 胱抑素C 同型半胱氨酸 糖化血红蛋白 

分 类 号：R587.2[医药卫生—内分泌]