核酸适配体在病毒检测中的研究进展  

Progress on Aptamer in Virus Detection

作　　者：李敏思[1] 伏小平[1] 宋战昀[2] 付志金[3] 

机构地区：[1]甘肃农业大学,甘肃兰州730070 [2]吉林出入境检验检疫局,吉林长春130062 [3]吉林农业大学,吉林长春130118

出　　处：《动物医学进展》2013年第7期96-100,共5页Progress In Veterinary Medicine

基　　金：国家自然科学基金项目(31001065)

摘　　要：核酸适配体指利用SELEX技术筛选出的寡聚核苷酸片段,它可以特异性地识别靶标并与之结合,且该技术具有成本低、亲和力高、特异性强等优点。目前,核酸适配体已广泛地应用于基础研究、临床诊断、疾病治疗等多领域,并且显示出巨大的应用潜力。结合近年来核酸适配体在病毒检测研究领域的最新研究成果,凭借适配体独特的性质在检测方面发挥的重要作用,综述了核酸适配体在人类免疫缺陷病病毒、肝炎病毒、流感病毒、SARS病毒等病毒检测方面的最新研究进展,展望了核酸适配体在病毒检测领域的发展趋势。Aptamer is oligonucleotide fragment selected by using SELEX technology,it could specifically identity target and bond to the target,and this technology has advantages of low cost,high affinity and strong specificity,etc.Currently aptamer is already widely used in various fields such as basic research,clinical diagnosis and disease treatment,and it shows great application potential.Combined with its lastest research result in virus detection research field,and by virtue of its important role in detection with unique property,this paper summarized the lastest reaserch progress made in virus detection such as detaction of human immunodeficiency virus,hepatitis virus,influenza virus and SARA virus.The paper also prospected the development trend of aptamer in virus detection field.

关 键 词：SELEX 病毒 适配体 

分 类 号：S855.3[农业科学—临床兽医学]