APS对2-DM胰岛素抵抗大鼠PPAR-γ mRNA表达的影响  

Effect of Astragalus Polysaccharides on Insulin Resistance and Gene Expression of PPAR-γ in Type 2 Diabetes Mellitus Rats

作　　者：刘洪凤[1] 宋铁军[2] 宋宇亮[1] 韩智学[1] 

机构地区：[1]牡丹江医学院生物化学教研室,黑龙江牡丹江157011 [2]牡丹江医学院第二附属医院,黑龙江牡丹江157011

出　　处：《中国食物与营养》2013年第6期70-71,共2页Food and Nutrition in China

基　　金：黑龙江省教育厅科学技术研究项目(项目编号:11551523)

摘　　要：目的:探讨黄芪多糖(APS)对2型糖尿病(2-DM)胰岛素抵抗(Insulin Resistance,IR)大鼠心肌组织过氧化物酶体增殖物激活受体-γ(PPAR-γ)基因表达的影响。方法:将Wistar大鼠随机分为正常对照组、模型组,APS高、中、低剂量治疗组。用药12周后,RT-PCR检测PPAR-γmRNA基因表达水平。结果:APS高、中剂量治疗组PPAR-γmRNA表达高于模型组。结论:APS可上调2-DM大鼠PPAR-γmRNA表达,从而实现其降低IR作用。[Objective] To investigate the effect of astragalus polysaccharides （APS） on the expression of PPAR-γ mRNA of insulin re-sistance （IR） rats with type 2 diabetes mellitus （2-DM） . [Method] Wistar rats were randomly divided into the control, model, and high, middle, low doses of APS groups. The mRNA expression of PPAR-γ was metered by RT-PCR at the end of 12 weeks. [Result] The mRNA expression of PPAR-γ, gene was increased in the middle and high doses of Alas groups. [Conclusion] APS could decrease IR by in-creasing mRNA expression of PPAR-γ gene in 2-DM rats.

关 键 词：黄芪多糖 2型糖尿病 胰岛素抵抗 过氧化物酶体增殖物激活受体-Γ 

分 类 号：R285.5[医药卫生—中药学]