α-硫辛酸治疗Ⅱ型糖尿病周围神经病变临床疗效观察  

Clinical Effect Observation of α-Thioctic acid in the Treatment of Mecobalamine Diabetes with Peripheral Neuropathy

作　　者：陈杨[1] 吴利平[1] 张小云[1] 范建生[1] 张传明[1] 

机构地区：[1]中国十九冶集团有限公司职工医院心内内分泌科,四川攀枝花617023

出　　处：《西部医学》2013年第7期990-991,共2页Medical Journal of West China

摘　　要：目的观察静脉滴注α-硫辛酸(ALA)注射液与静滴甲钴胺注射液治疗Ⅱ型糖尿病周围神经病变(DPN)临床疗效。方法将80例患者分别用0.9%氯化钠注射液250ml加入α-硫辛酸注射液0.6静脉滴注1次/日(A组40例)与0.9%氯化钠注射液250ml加入甲钴胺注射液0.5mg静脉滴注1次/日(B组40例),共2周,对四肢皮肤溃烂,经久不愈的创面患者坚持换药、清创,观察患者临床症状缓解程度。结果 A组:显效15例,占37.5%;有效23例,占57.5%;无效2例,占5%;无明显副作用,总有效率95%。B组:显效10例,占25.0%;有效19例,占47.5%;无效11,占27.5%;无明显副作用,总有效率72.5%。A组有效率明显高于B组(P<0.05)。结论α-硫辛酸注射液治疗Ⅱ型糖尿病周围神经病变能明显改善患者临床症状,疗效确切,安全性好,可以广泛应用于临床,尤其是基层医院。Objective To observe the clinical effects of ALA and DPN in the treatment of DPN.Methods 250ml 0.9% sodium chloride injection ＋ 0.6g ALA were used for intraveous drip once a day（Group A） and 250ml 0.9% sodium chloride injection ＋ 0.5 mg mecobalamin injection for intraveous drip once a day（Group B）.The treatment lasted for 2 weeks,the patients＇ clinical remission status were observed.Results In Group A,15 cases were significantly effective（37.5%）,23 cases were effective（57.5%）,2 cases were not effective（5%） and no side-effect was observed;in Group B,10 cases were significantly effective（25%）,19 cases were effective（47.5%）,11 cases were not effective（27.5%） and no side-effect was observed.The effective rate in Group A（95%） was higher than that in Group B（72.5%）（P0.05）.Conclusion ALA can obviously improve the clinical status of patients with ensured effective effects safely,which can be widely applied to the clinical treatment especially in basic level hospitals.

关 键 词：硫辛酸 甲钴胺 糖尿病 周围神经病变 

分 类 号：R587.1[医药卫生—内分泌]