慢性HBV感染不同免疫状态中医证型特点的研究  

Features of TCM Syndromes of Different Immune State with Chronic HBV Infection

作　　者：杨丽莎[1] 梁志清[1] 范剑薇[1] 吴淋淋[1] 苏元英[1] 张兵[1] 刘凌生[1] 

机构地区：[1]桂林医学院附属医院,广西桂林541001

出　　处：《南京中医药大学学报》2013年第4期324-326,共3页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：国家自然科学基金(81260602);广西科学研究与技术开发计划项目(桂科攻10124001B);桂林市科学研究与技术开发计划项目(20070513)

摘　　要：目的了解慢性HBV感染不同免疫状态中医证型分布特点。方法采用免疫学分类、中医辨证分型及临床流行病学调查等方法,对慢性HBV感染免疫耐受、免疫清除和免疫不全状态各200例进行中医证型分布特点研究。结果慢性HBV感染3个不同免疫状态组出现的证型均有肝郁脾虚、肝肾阴虚、肝郁气滞、湿热内蕴、脾气虚、气阴不足、心肝郁热、肝血虚、肺脾气虚、血瘀、脾肾阳虚等。经卡方检验,P<0.05,表明3种不同免疫状态间的中医证型分布差异具有统计学意义,在免疫耐受状态组以肝郁脾虚为主,免疫清除状态组以湿热内蕴为主,免疫不全状态组以肝肾阴虚为主。结论 HBV感染不同免疫状态中医证型分布特点不同,可为中西医结合防治慢性HBV感染的临床诊断和疗效评价提供理论依据。OBJECTIVE To investigate distribution characteristics of TCM syndromes of different immune state with chronic HBV infection.METHODS Immunological classification,TCM syndrome classification,and clinical epidemiology methods were applied to investigate distribution characteristics of TCM syndromes of 200 cases of immune tolerance,200 immune clearance and 200 immunodeficiency with chronic HBV infection.RESULTS Syndromes of chronic HBV infection in three different immune status groups are liver stagnation and spleen deficiency,yin deficiency of liver and kidney,liver qi stagnation,accumulation of damp-heat,qi deficiency,yin deficiency,liver and stomach,deficiency of liver blood,lung and spleen deficiency,blood stasis,deficiency of spleen and kidney yang.The chi-square test showed P＜0.05,suggesting that TCM syndrome distribution of three kinds of immune states was of statistics significance.The state of immune tolerance,immune clearance,and immunodeficiency gave the first place to liver stagnation,internal increase of dampness and heat and yin deficiency of liver and kidney,respectively.CONCLUSION TCM syndromes distribute to different immune states of HBV infection,which could provide theoretical basis for clinical diagnosis and efficacy evaluation of prevention and treatment of chronic HBV infection by the integration of TCM and western medicine.

关 键 词：HBV感染 免疫耐受 免疫清除 免疫不全 中医证型 

分 类 号：R256.4[医药卫生—中医内科学]