试论溃疡性结肠炎的中药新药研究思路  

Research Ideas on New Chinese Medicine Drug in the Treatment of Ulcerative Colitis

作　　者：刘珺瑶 辛宁[1] 周福军[2] 单淇[2] 于冰[2] 侯文彬[2] 

机构地区：[1]广西中医药大学药学院,广西530001 [2]天津药物研究院/天津中药制剂与质量控制技术国家地方联合工程实验室,天津300193

出　　处：《世界科学技术-中医药现代化》2013年第3期495-500,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：科学技术部国家科技支撑计划(2007BAI41B06):中药天然药成药性综合评价的关键技术及其应用研究;负责人:侯文彬

摘　　要：溃疡性结肠炎(UC)是一种直肠和结肠慢性非特异性疾病,病因尚不明确,常反复发作,治疗难度较大,严重影响患者日常的生活和工作。针对中医药治疗溃疡性结肠炎疾病现状及存在问题,结合本人对新药研发的体会,提出治疗UC的中药新药研究思路,包括建立符合中医药特色的作用机制及UC动物模型,选择合适的临床治疗点等。Ulcerative colitis（UC） is a chronic non-specific disease of the rectum and colon.The disease cause is still unclear.Due to the repeated episodes of UC,the treatment is very difficult.There are serious impact on pa tients’ life and work.According to the current UC condition and existed problems with Chinese medicine treatment and in combination with experiences of new Chinese medicine drug development of the author,a new Chi nese medicine drug research idea of UC has been proposed.It includes the establishment of UC animal model in line with the characteristics of Chinese medicine and the selection of appropriate clinical treatment targets.

关 键 词：溃疡性结肠炎 UC作用机制 UC动物模型 

分 类 号：R285[医药卫生—中药学]