基于Discovery Studio软件解析五味子乙素的电喷雾/质谱裂解途径  

ESI /MS Study on Fragmentation Pathways of Schisandrin B by the Discovery Studio

作　　者：贺锐锐[1] 谭鹏[2] 韩静[2] 林宏英[2] 陈鑫[3] 刘永刚[2] 张燕玲[2] 

机构地区：[1]北京大学第一医院药理所,北京100191 [2]北京中医药大学中药学院,北京100029 [3]北京大学医学部,北京100191

出　　处：《世界科学技术-中医药现代化》2013年第3期527-530,共4页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委青年基金项目(30901959):基于质谱裂解规律和量子化学预测乌头碱代谢规律研究;负责人:刘永刚

摘　　要：目的:基于Discovery Studio软件研究五味子乙素的质谱裂解机制。方法:在正离子模式,用线性离子阱质谱得到五味子乙素的质谱图。结果:通过Discovery Studio解析五味子乙素多级质谱碎片,主要发生环的开裂,H2O,-CH3和-OCH3等自由基丢失。结论:本研究丰富五味子乙素的质谱裂解机制,为木脂素类成分的结构鉴定研究提供依据。This study was aimed to find the fragmentation pathways of Schisandrin B using the Discovery Studio by electrospray ionization mass spectrometry（ESI-MSn）.The first and multi-stage mass spectrum diagrams were obtained.The results showed that mass spectrometry fragments of Schisandrin B was analyzed under the positive mode,the cracking rings are mainly occurred,and free radicals such as H2O,-CH3 and-OCH3 were lost.It was concluded that this study enriched the mass spectral decomposition,and provided basis for the study on chemical constituents of lignan compounds.

关 键 词：五味子乙素 ESI-MS MS 裂解途径 

分 类 号：R284.1[医药卫生—中药学]