血压参数对高血压病患者记忆功能影响  

Relationship between blood pressure level and cognitive impairment in hypertension patients

作　　者：陈长香[1] 郝英秀[1] 王建辉[1] 李建民[2] 

机构地区：[1]河北联合大学护理与康复学院,河北唐山063000 [2]河北联合大学神经病学研究所

出　　处：《中国公共卫生》2013年第7期965-968,共4页Chinese Journal of Public Health

基　　金：河北省科技厅科技支撑项目(2009276103D-7)

摘　　要：目的探讨血压参数对高血压患者记忆功能的影响,为延缓和预防高血压患者发展为血管性痴呆采取干预措施提供科学依据。方法随机选取2010年9—12月在河北省唐山市工人医院就诊的196例高血压病患者(I级66例、II级64例、III级66例)进行记忆功能测评。结果高血压I级患者患轻、中、重度记忆功能障碍者的比例分别为59.1%、30.3%、6.1%,高血压II级患者患轻、中、重度记忆功能障碍者的比例分别为32.8%、53.1%、9.4%,高血压III级患者患轻、中、重度记忆功能障碍者的比例分别为24.2%、56.1%、13.6%,不同分级高血压患者记忆障碍发生率不同(χ2=10.389,P=0.006);高血压I、II、III级患者行为记忆测验第二版(RBMTⅡ)评分比较,不同分级高血压患者回忆姓名、回忆被藏物品、脸部再认、路线延迟回忆、定向评分和记忆标准总分间差异均有统计学意义(P<0.05);相关分析结果表明,RBMTⅡ标准总分与收缩压及脉压均呈负相关(P=0.000),与舒张压无相关(P>0.05);多元线性逐步回归分析结果表明,年龄越大、脉压越大,高血压患者RBMTⅡ标准总分越低,受教育年限越高,高血压患者RBMTⅡ标准总分越高。结论高血压患者的记忆功能障碍以长时记忆功能损害为主;高血压患者血压可影响其记忆功能,尤其以脉压最为明显。Objective To explore the association of systolic blood pressure（SBP）,pulses pressure（PP）,and diastolic blood pressure（DBP） with cognitive impairment among hypertension patients and to provide evidence for the prevention of cognitive impairment.Methods A total of 196 hypertensives（66 in stage I,64 in stage II,and 66 in stage III） were randomly chosen from Tangshan Worker’s Hospital.Cognitive function was measured with Rivermead Behavioural Memory Test Second Edition（RBMT-Ⅱ,2003）.Results The incidences of memory disorder among the hypertension patients at different disease stages were different（χ2 =10.389,P=0.006）.The proportions of mild,moderate,and severe memory disoder were 53.1%,30.3%,and 6.1% for the patients with stage I hypertension,32.8%,53.1%,and 9.4% for the patients at stage II,and 24.2%,56.1%,and 13.6% for the patients at stage III,respectively.There were significant differences in the scores for items of recall name,remember storing articles,recall of faces,delayed route,orientation score and RBMT-Ⅱ total score among the hypertension patients at different disease stages（P＆lt;0.05）.The RBMT-Ⅱ total score was inversely related to SBP and PP（P=0.000）,but not related to DBP（P＆gt;0.05）.Multiple linear stepwise regression indicated that RBMT-Ⅱ total score was inversely related to the increase of age and PP but correlated positively with education level among the patients.Conclusion Blood pressure,especially PP,may affect long-term memory in patients with hypertension.

关 键 词：收缩压 舒张压 脉压 记忆功能 高血压患者 

分 类 号：R544.1[医药卫生—心血管疾病]