孕妇乙肝表面抗体对儿童乙肝疫苗接种效果的长期影响  

Long-term effects of maternal positive-HBsAb on children with hepatitis B vaccine

作　　者：吴限[1] 高夕雷[1] 吴凤会[1] 钱雷[1] 

机构地区：[1]滨海县人民医院,江苏盐城224500

出　　处：《现代预防医学》2013年第14期2614-2616,共3页Modern Preventive Medicine

基　　金：盐城市医学科技发展基金资助项目(YK2010082)

摘　　要：目的了解孕妇乙肝表面抗体(抗HBs)对儿童乙肝疫苗接种效果的长期影响。方法研究对象为106例抗HBs阳性和109例抗HBs阴性孕妇及其婴儿,检测孕妇产时外周血和新生儿脐带血抗HBs浓度,婴儿出生后接种5ug乙肝疫苗(0、1、6月),在儿童1岁半时检测血液抗HBs浓度。结果抗HBs阳性孕妇的新生儿脐带血中均含有抗HBs,84.9%的新生儿脐带血抗HBs浓度高于母亲外周血,抗HBs阳性孕妇组和抗HBs阴性孕妇组的儿童在1岁半时外周血抗HBs阳性率分别为89.6%和87.1%(P﹥0.05),抗HBs浓度几何均数分别为79.5IU/L和78.7IU/L(P﹥0.05),差异均无显著性。结论母亲乙肝表面抗体不影响儿童乙肝疫苗接种的长期效果。OBJECTIVE To investigate long-term effects of maternal positive-HBsAb on children with hepatitis B vaccine. METHODS 215 pairs of mothers and children were enrolled including 106 anti -HBs positive mothers and 109 anti -HBs negative mothers. All infants were routinely vaccinated against hepatitis B based on 0- , 1- and 6-month schedule. At the age of one and half years, the concentration of serum anti-HBs of childhood was observed. RESULTS All 106 anti-HBs positive mothers transferred anti-HBs to their infants and 84.9% of the infants had higher anti-HBs concentrations than their mothers. One and half years after vaccination with three doses of hepatitis B vaccine, the positive rate and geometric mean concentration （GMC） of anti-HBs in infants with maternal anti-HBs compared with those in infants without maternal antibody were 89.6% vs 87.1% （P﹥0.05） and 79.5 IU / L vs 78.7 IU / L （P﹥0.05） respectively. CONCLUSION Maternal anti-HBs in infants do not inhibit the long-term immunogenicity of hepatitis B vaccine.

关 键 词：乙肝疫苗 乙肝表面抗体 回顾性调查 

分 类 号：R373.2[医药卫生—病原生物学]