冠心病不稳定型心绞痛与MMP-1、MMP-2、MMP-3相关性研究  

Relationship Between Unstable Angina Pectoris CHD and MMP-1,MMP-2 and MMP-3

作　　者：王莹威[1] 蒋宁[1] 高嵩山[1] 魏明慧[1] 

机构地区：[1]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040

出　　处：《辽宁中医杂志》2013年第7期1330-1331,共2页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的:研究冠心病不稳定型心绞痛(UA)患者血清MMP-1、MMP-2、MMP-3的表达,并探讨其与冠状动脉狭窄程度和斑块不稳定性之间的关系。方法:分离出30例UA和30例CPS患者血清,采用酶联免疫吸附法(ELISA)检测其中的MMP-1、MMP-2、MMP-3表达水平,并进行相关性研究。结果:UA和CPS组患者血清中MMP-1、MMP-2、MMP-3有统计学意义(P<0.005)。结论:冠心病不稳定型心绞痛患者血清中MMP-1、MMP-2、MMP-3表达水平增高,提示其可能是动脉粥样硬化不稳定斑块的发病机制之一。Objective：To investigate patients with unstable angina（UA）serum expressions of MMP-1,MMP-2 and MMP-3,and explore the relationship between the coronary stenosis and plaque instability.Methods：The serum from 30 patients with UA and 30 patients with CPS was isolated in which MMP-1,MMP-2,MMP-3 expression levels were tested by enzyme-linked immunosorbent assay（ELISA）,and related research was carried on.Results：UA and CPS groups′ MMP-1,MMP-2,MMP-3 expressions had statistical significance（P0.005）.Conclusion：The serum expression levels of MMP-1,MMP-2 and MMP-3 in coronary heart disease patients with unstable angina were increased,suggesting that it may be one of the unstable plaque pathogenesis of atherosclerosis.

关 键 词：冠心病不稳定型心绞痛 MMP-1 MMP-2 MMP-3 不稳定斑块 

分 类 号：R541.4[医药卫生—心血管疾病]