斑马鱼在药物早期毒性筛选中的应用进展  

Progress of application of zebrafish in early drug toxicology screening

作　　者：常嘉 陆亮 王庆利[2] 常艳 马璟 

机构地区：[1]中国医药工业研究总院国家上海新药安全评价研究中心,上海201203 [2]国家食品药品监督管理局药品审评中心,北京100038

出　　处：《中国新药杂志》2013年第13期1500-1504,共5页Chinese Journal of New Drugs

基　　金：国家"重大新药创制"科技重大专项(2012ZX09505001-003)

摘　　要：斑马鱼作为一种较理想的模式生物早在上世纪便应用于环境毒性的评价,并得到了世界的公认。但其应用于药物毒理学却相对比较滞后。近些年来随着对斑马鱼的深入研究以及其本身具有的优势,得到了药物毒理学家的重视。本文对斑马鱼应用于药物早期筛选的优势及存在的不足进行了简单概述,并对其近年来的在早筛中的应用进展进行了综述。Zebrafish, as an ideal model organism, was applied to the evaluation of the environmental toxic- ity in the last century and well recognized by the world. However, its application in drug toxicology study was rela- tively behind. In recent years, with the in-depth studies of zebrafish as well as the advantage of zebrafish itself, it has got more attention of drug toxicologists. The advantages and shortcomings of using zebrafish in early drug screening and the development in recent years are reviewed in this paper.

关 键 词：斑马鱼 模式动物 早筛 

分 类 号：R965[医药卫生—药理学]