非晶态给药体系的形成机制与制备工艺的研究进展  

The progress of research on the formation mechanism and preparation process of amorphous drug delivery system

作　　者：王杏林[1] 王频[1,2] 尹东东[1] 

机构地区：[1]天津药物研究院释药技术与药动学国家重点实验室,天津300193 [2]河南大学药学院,开封475001

出　　处：《中国新药杂志》2013年第13期1538-1544,共7页Chinese Journal of New Drugs

基　　金：国家重点基础研究发展计划(973计划)课题(2012CB724002)

摘　　要：非晶态作为一种高能态的给药形式,能够有效地改善水难溶性药物的水溶性和生物利用度。热力学和动力学的平衡是非晶态给药体系保持稳定的本质,也是非晶态制备过程中决定制备工艺难易的主导因素。超临界CO2介导、单相低压冷冻干燥、静电纺丝、微波辐射、超声悬浮等新型技术以及多孔介质和新型混凝剂等新型材料的应用,在改善非晶态给药体系的动力学和热力学稳定性方面发挥了较为优势的作用。在本文中,对非晶态给药体系的形成机制与稳定性的相关研究以及制备工艺的新进展进行综述。At high-energy state, amorphous drug delivery system can improve the solubility and bioavail- ability of poorly water-soluble drugs effectively. The balance between thermodynamics and kinetics is the natural reason for amorphous drug delivery system to maintain stable, and also determines the difficulty of preparing process. The new preparing technologies such as supercritical CO2-mediated method, lyophilization monophase so- lution technique, electro-spinning, microwaves irradiation, acoustic levitation and the application of new materials as porous media and new coagulants play important roles in improving dynamic and thermodynamic stability of amor- phous drug delivery system. This article gives an overview on the formation mechanism, research on stability, and progress in preparing technology of the amorphous drug delivery system.

关 键 词：非晶态 机制 稳定性 制备工艺 固体分散体 

分 类 号：R979.1[医药卫生—药品]